Cargando…

Suppression of prostate cancer progression by cancer cell stemness inhibitor napabucasin

A small population of cells with stem cell‐like properties in prostate cancer (PCa), called prostate cancer stem cells (PrCSCs) or prostate stemness‐high cancer cells, displays highly tumorigenic and metastatic features and may be responsible for the therapy resistance. A small molecule, napabucasin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Yiming, Jin, Zhong, Zhou, Huimin, Ou, Xueting, Xu, Yawen, Li, Hulin, Liu, Chunxiao, Li, Bingkun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Cancer Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924383/ https://www.ncbi.nlm.nih.gov/pubmed/26899963 http://dx.doi.org/10.1002/cam4.675

Ejemplares similares

Napabucasin Reduces Cancer Stem Cell Characteristics in Hepatocellular Carcinoma
por: Li, Ya, et al.
Publicado: (2020)

Napabucasin, a novel STAT3 inhibitor suppresses proliferation, invasion and stemness of glioblastoma cells
por: Han, Dongfeng, et al.
Publicado: (2019)

Phase 1 study of napabucasin, a cancer stemness inhibitor, in patients with advanced solid tumors
por: Kawazoe, Akihito, et al.
Publicado: (2020)

Targeting MTA1/HIF‐1α signaling by pterostilbene in combination with histone deacetylase inhibitor attenuates prostate cancer progression
por: Butt, Nasir A., et al.
Publicado: (2017)

Stimulation of hypothalamic oxytocin neurons suppresses colorectal cancer progression in mice
por: Pan, Susu, et al.
Publicado: (2021)

Inhibition of prostate cancer growth by solanine requires the suppression of cell cycle proteins and the activation of ROS/P38 signaling pathway
por: Pan, Bin, et al.
Publicado: (2016)

Geraniol suppresses prostate cancer growth through down‐regulation of E2F8
por: Lee, Sanghoon, et al.
Publicado: (2016)

IgG silencing induces apoptosis and suppresses proliferation, migration and invasion in LNCaP prostate cancer cells
por: Xu, Yawen, et al.
Publicado: (2016)

Upregulation of hsa_circ_0007874 suppresses the progression of ovarian cancer by regulating the miR‐760/SOCS3 pathway
por: Li, Li, et al.
Publicado: (2020)

Defining cellular population dynamics at single-cell resolution during prostate cancer progression
por: Germanos, Alexandre A, et al.
Publicado: (2022)

Tris–base buffer: a promising new inhibitor for cancer progression and metastasis
por: Ibrahim‐Hashim, Arig, et al.
Publicado: (2017)

A novel hedgehog inhibitor iG2 suppresses tumorigenesis by impairing self‐renewal in human bladder cancer
por: Zhu, Lihong, et al.
Publicado: (2016)

MEIS-mediated suppression of human prostate cancer growth and metastasis through HOXB13-dependent regulation of proteoglycans
por: VanOpstall, Calvin, et al.
Publicado: (2020)

Napabucasin Induces Mouse Bone Loss by Impairing Bone Formation via STAT3
por: Huang, Xiangru, et al.
Publicado: (2021)

Downregulation of NDR1 contributes to metastasis of prostate cancer cells via activating epithelial‐mesenchymal transition
por: Yue, Juntao, et al.
Publicado: (2018)

Mitochondrial Acetyl‐CoA Synthetase 3 is Biosignature of Gastric Cancer Progression
por: Chang, Wei‐Chun, et al.
Publicado: (2018)

Long noncoding RNA TCONS_00026334 is involved in suppressing the progression of colorectal cancer by regulating miR‑548n/TP53INP1 signaling pathway
por: Zhu, Mingming, et al.
Publicado: (2020)

BET inhibitor JQ1 suppresses cell proliferation via inducing autophagy and activating LKB1/AMPK in bladder cancer cells
por: Li, Feng, et al.
Publicado: (2019)

MiR‐362 suppresses cervical cancer progression via directly targeting BAP31 and activating TGFβ/Smad pathway
por: Yang, Shuya, et al.
Publicado: (2020)

TLE3 loss confers AR inhibitor resistance by facilitating GR-mediated human prostate cancer cell growth
por: Palit, Sander AL, et al.
Publicado: (2019)

LIMD1‐AS1 suppressed non‐small cell lung cancer progression through stabilizing LIMD1 mRNA via hnRNP U
por: Pan, Jianyuan, et al.
Publicado: (2020)

YY1 directly suppresses MYCT1 leading to laryngeal tumorigenesis and progress
por: Qu, Si‐Yao, et al.
Publicado: (2017)

Olfactomedin 4 downregulation is associated with tumor initiation, growth and progression in human prostate cancer
por: Li, Hongzhen, et al.
Publicado: (2019)

The Cancer Stem Cell Inhibitor Napabucasin (BBI608) Shows General Cytotoxicity in Biliary Tract Cancer Cells and Reduces Cancer Stem Cell Characteristics
por: Beyreis, Marlena, et al.
Publicado: (2019)

The CIC-ERF co-deletion underlies fusion-independent activation of ETS family member, ETV1, to drive prostate cancer progression
por: Gupta, Nehal, et al.
Publicado: (2022)

Napabucasin Attenuates Resistance of Breast Cancer Cells to Tamoxifen by Reducing Stem Cell-Like Properties
por: Liu, Xueni, et al.
Publicado: (2019)

Prostate cancer as a dedifferentiated organ: androgen receptor, cancer stem cells, and cancer stemness
por: Liu, Xiaozhuo, et al.
Publicado: (2022)

Overexpression of claspin promotes docetaxel resistance and is associated with prostate‐specific antigen recurrence in prostate cancer
por: Babasaki, Takashi, et al.
Publicado: (2021)

Calpain‐2 inhibitor treatment preferentially reduces tumor progression for human colon cancer cells expressing highest levels of this enzyme
por: Marciel, Michael P., et al.
Publicado: (2017)

Expression and ERG regulation of PIM kinases in prostate cancer
por: Eerola, Sini K., et al.
Publicado: (2021)

How splicing confers treatment resistance in prostate cancer
por: Konda, Prathyusha, et al.
Publicado: (2022)

Revisiting the roles of cAMP signalling in the progression of prostate cancer
por: Parsons, Emma C., et al.
Publicado: (2023)

Mitochondrial respiratory gene expression is suppressed in many cancers
por: Reznik, Ed, et al.
Publicado: (2017)

TOB1 suppresses proliferation in K‐Ras wild‐type pancreatic cancer
por: Bai, Yuru, et al.
Publicado: (2019)

Oxymatrine inhibits non–small cell lung cancer via suppression of EGFR signaling pathway
por: Li, Wei, et al.
Publicado: (2017)

Repurposing Napabucasin as an Antimicrobial Agent against Oral Streptococcal Biofilms
por: Kuang, Xinyi, et al.
Publicado: (2020)

Hypoxia‐responsive miR‐124 and miR‐144 reduce hypoxia‐induced autophagy and enhance radiosensitivity of prostate cancer cells via suppressing PIM1
por: Gu, Hao, et al.
Publicado: (2016)

Antigen presentation and tumor immunogenicity in cancer immunotherapy response prediction
por: Wang, Shixiang, et al.
Publicado: (2019)

Generation of a Novel Dendritic-cell Vaccine Using Melanoma and Squamous Cancer Stem Cells
por: Li, Qiao, et al.
Publicado: (2014)

Cancer‐associated fibroblasts secrete Wnt2 to promote cancer progression in colorectal cancer
por: Aizawa, Takashi, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_idvhg4e5l1gn1p1m4lkmhaaqc5