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Long‐term risk of gastrointestinal cancers in persons with gastric or duodenal ulcers

Peptic ulcer predicts gastric cancer. It is controversial if peptic ulcers predict other gastrointestinal cancers, potentially related to Helicobacter pylori or shared lifestyle factors. We hypothesized that gastric and duodenal ulcers may have different impact on the risk of gastrointestinal cancer...

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Autores principales: Søgaard, Kirstine K., Farkas, Dóra K, Pedersen, Lars, Lund, Jennifer L., Thomsen, Reimar W., Sørensen, Henrik T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924392/
https://www.ncbi.nlm.nih.gov/pubmed/26923747
http://dx.doi.org/10.1002/cam4.680
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author Søgaard, Kirstine K.
Farkas, Dóra K
Pedersen, Lars
Lund, Jennifer L.
Thomsen, Reimar W.
Sørensen, Henrik T.
author_facet Søgaard, Kirstine K.
Farkas, Dóra K
Pedersen, Lars
Lund, Jennifer L.
Thomsen, Reimar W.
Sørensen, Henrik T.
author_sort Søgaard, Kirstine K.
collection PubMed
description Peptic ulcer predicts gastric cancer. It is controversial if peptic ulcers predict other gastrointestinal cancers, potentially related to Helicobacter pylori or shared lifestyle factors. We hypothesized that gastric and duodenal ulcers may have different impact on the risk of gastrointestinal cancers. In a nationwide cohort study using Danish medical databases 1994–2013, we quantified the risk of gastric and other gastrointestinal cancers among patients with duodenal ulcers (dominantly H. pylori‐related) and gastric ulcers (dominantly lifestyle‐related) compared with the general population. We started follow‐up 1‐year after ulcer diagnosis to avoid detection bias and calculated absolute risks of cancer and standardized incidence ratios (SIRs). We identified 54,565 patients with gastric ulcers and 38,576 patients with duodenal ulcers. Patient characteristics were similar in the two cohorts. The 1–5‐year risk of any gastrointestinal cancer was slightly higher for gastric ulcers patients (2.1%) than for duodenal ulcers patients (2.0%), and SIRs were 1.38 (95% CI: 1.31–1.44) and 1.30 (95% CI: 1.23–1.37), respectively. The SIR of gastric cancer was higher among patients with gastric ulcer than duodenal ulcer (1.92 vs. 1.38), while the SIRs for other gastrointestinal cancers were similar (1.33 vs. 1.29). Compared with gastric ulcer patients, duodenal ulcer patients were at lower risk of smoking‐ and alcohol‐related gastrointestinal cancers. The risk of nongastric gastrointestinal cancers is increased both for patients with gastric ulcers and with duodenal ulcers, but absolute risks are low. H. pylori may be less important for the development of nongastric gastrointestinal cancer than hypothesized.
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spelling pubmed-49243922016-06-29 Long‐term risk of gastrointestinal cancers in persons with gastric or duodenal ulcers Søgaard, Kirstine K. Farkas, Dóra K Pedersen, Lars Lund, Jennifer L. Thomsen, Reimar W. Sørensen, Henrik T. Cancer Med Cancer Prevention Peptic ulcer predicts gastric cancer. It is controversial if peptic ulcers predict other gastrointestinal cancers, potentially related to Helicobacter pylori or shared lifestyle factors. We hypothesized that gastric and duodenal ulcers may have different impact on the risk of gastrointestinal cancers. In a nationwide cohort study using Danish medical databases 1994–2013, we quantified the risk of gastric and other gastrointestinal cancers among patients with duodenal ulcers (dominantly H. pylori‐related) and gastric ulcers (dominantly lifestyle‐related) compared with the general population. We started follow‐up 1‐year after ulcer diagnosis to avoid detection bias and calculated absolute risks of cancer and standardized incidence ratios (SIRs). We identified 54,565 patients with gastric ulcers and 38,576 patients with duodenal ulcers. Patient characteristics were similar in the two cohorts. The 1–5‐year risk of any gastrointestinal cancer was slightly higher for gastric ulcers patients (2.1%) than for duodenal ulcers patients (2.0%), and SIRs were 1.38 (95% CI: 1.31–1.44) and 1.30 (95% CI: 1.23–1.37), respectively. The SIR of gastric cancer was higher among patients with gastric ulcer than duodenal ulcer (1.92 vs. 1.38), while the SIRs for other gastrointestinal cancers were similar (1.33 vs. 1.29). Compared with gastric ulcer patients, duodenal ulcer patients were at lower risk of smoking‐ and alcohol‐related gastrointestinal cancers. The risk of nongastric gastrointestinal cancers is increased both for patients with gastric ulcers and with duodenal ulcers, but absolute risks are low. H. pylori may be less important for the development of nongastric gastrointestinal cancer than hypothesized. John Wiley and Sons Inc. 2016-02-29 /pmc/articles/PMC4924392/ /pubmed/26923747 http://dx.doi.org/10.1002/cam4.680 Text en © 2016 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Cancer Prevention
Søgaard, Kirstine K.
Farkas, Dóra K
Pedersen, Lars
Lund, Jennifer L.
Thomsen, Reimar W.
Sørensen, Henrik T.
Long‐term risk of gastrointestinal cancers in persons with gastric or duodenal ulcers
title Long‐term risk of gastrointestinal cancers in persons with gastric or duodenal ulcers
title_full Long‐term risk of gastrointestinal cancers in persons with gastric or duodenal ulcers
title_fullStr Long‐term risk of gastrointestinal cancers in persons with gastric or duodenal ulcers
title_full_unstemmed Long‐term risk of gastrointestinal cancers in persons with gastric or duodenal ulcers
title_short Long‐term risk of gastrointestinal cancers in persons with gastric or duodenal ulcers
title_sort long‐term risk of gastrointestinal cancers in persons with gastric or duodenal ulcers
topic Cancer Prevention
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924392/
https://www.ncbi.nlm.nih.gov/pubmed/26923747
http://dx.doi.org/10.1002/cam4.680
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