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Long‐term risk of gastrointestinal cancers in persons with gastric or duodenal ulcers
Peptic ulcer predicts gastric cancer. It is controversial if peptic ulcers predict other gastrointestinal cancers, potentially related to Helicobacter pylori or shared lifestyle factors. We hypothesized that gastric and duodenal ulcers may have different impact on the risk of gastrointestinal cancer...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924392/ https://www.ncbi.nlm.nih.gov/pubmed/26923747 http://dx.doi.org/10.1002/cam4.680 |
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author | Søgaard, Kirstine K. Farkas, Dóra K Pedersen, Lars Lund, Jennifer L. Thomsen, Reimar W. Sørensen, Henrik T. |
author_facet | Søgaard, Kirstine K. Farkas, Dóra K Pedersen, Lars Lund, Jennifer L. Thomsen, Reimar W. Sørensen, Henrik T. |
author_sort | Søgaard, Kirstine K. |
collection | PubMed |
description | Peptic ulcer predicts gastric cancer. It is controversial if peptic ulcers predict other gastrointestinal cancers, potentially related to Helicobacter pylori or shared lifestyle factors. We hypothesized that gastric and duodenal ulcers may have different impact on the risk of gastrointestinal cancers. In a nationwide cohort study using Danish medical databases 1994–2013, we quantified the risk of gastric and other gastrointestinal cancers among patients with duodenal ulcers (dominantly H. pylori‐related) and gastric ulcers (dominantly lifestyle‐related) compared with the general population. We started follow‐up 1‐year after ulcer diagnosis to avoid detection bias and calculated absolute risks of cancer and standardized incidence ratios (SIRs). We identified 54,565 patients with gastric ulcers and 38,576 patients with duodenal ulcers. Patient characteristics were similar in the two cohorts. The 1–5‐year risk of any gastrointestinal cancer was slightly higher for gastric ulcers patients (2.1%) than for duodenal ulcers patients (2.0%), and SIRs were 1.38 (95% CI: 1.31–1.44) and 1.30 (95% CI: 1.23–1.37), respectively. The SIR of gastric cancer was higher among patients with gastric ulcer than duodenal ulcer (1.92 vs. 1.38), while the SIRs for other gastrointestinal cancers were similar (1.33 vs. 1.29). Compared with gastric ulcer patients, duodenal ulcer patients were at lower risk of smoking‐ and alcohol‐related gastrointestinal cancers. The risk of nongastric gastrointestinal cancers is increased both for patients with gastric ulcers and with duodenal ulcers, but absolute risks are low. H. pylori may be less important for the development of nongastric gastrointestinal cancer than hypothesized. |
format | Online Article Text |
id | pubmed-4924392 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-49243922016-06-29 Long‐term risk of gastrointestinal cancers in persons with gastric or duodenal ulcers Søgaard, Kirstine K. Farkas, Dóra K Pedersen, Lars Lund, Jennifer L. Thomsen, Reimar W. Sørensen, Henrik T. Cancer Med Cancer Prevention Peptic ulcer predicts gastric cancer. It is controversial if peptic ulcers predict other gastrointestinal cancers, potentially related to Helicobacter pylori or shared lifestyle factors. We hypothesized that gastric and duodenal ulcers may have different impact on the risk of gastrointestinal cancers. In a nationwide cohort study using Danish medical databases 1994–2013, we quantified the risk of gastric and other gastrointestinal cancers among patients with duodenal ulcers (dominantly H. pylori‐related) and gastric ulcers (dominantly lifestyle‐related) compared with the general population. We started follow‐up 1‐year after ulcer diagnosis to avoid detection bias and calculated absolute risks of cancer and standardized incidence ratios (SIRs). We identified 54,565 patients with gastric ulcers and 38,576 patients with duodenal ulcers. Patient characteristics were similar in the two cohorts. The 1–5‐year risk of any gastrointestinal cancer was slightly higher for gastric ulcers patients (2.1%) than for duodenal ulcers patients (2.0%), and SIRs were 1.38 (95% CI: 1.31–1.44) and 1.30 (95% CI: 1.23–1.37), respectively. The SIR of gastric cancer was higher among patients with gastric ulcer than duodenal ulcer (1.92 vs. 1.38), while the SIRs for other gastrointestinal cancers were similar (1.33 vs. 1.29). Compared with gastric ulcer patients, duodenal ulcer patients were at lower risk of smoking‐ and alcohol‐related gastrointestinal cancers. The risk of nongastric gastrointestinal cancers is increased both for patients with gastric ulcers and with duodenal ulcers, but absolute risks are low. H. pylori may be less important for the development of nongastric gastrointestinal cancer than hypothesized. John Wiley and Sons Inc. 2016-02-29 /pmc/articles/PMC4924392/ /pubmed/26923747 http://dx.doi.org/10.1002/cam4.680 Text en © 2016 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Cancer Prevention Søgaard, Kirstine K. Farkas, Dóra K Pedersen, Lars Lund, Jennifer L. Thomsen, Reimar W. Sørensen, Henrik T. Long‐term risk of gastrointestinal cancers in persons with gastric or duodenal ulcers |
title | Long‐term risk of gastrointestinal cancers in persons with gastric or duodenal ulcers |
title_full | Long‐term risk of gastrointestinal cancers in persons with gastric or duodenal ulcers |
title_fullStr | Long‐term risk of gastrointestinal cancers in persons with gastric or duodenal ulcers |
title_full_unstemmed | Long‐term risk of gastrointestinal cancers in persons with gastric or duodenal ulcers |
title_short | Long‐term risk of gastrointestinal cancers in persons with gastric or duodenal ulcers |
title_sort | long‐term risk of gastrointestinal cancers in persons with gastric or duodenal ulcers |
topic | Cancer Prevention |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924392/ https://www.ncbi.nlm.nih.gov/pubmed/26923747 http://dx.doi.org/10.1002/cam4.680 |
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