Camptothecin targets WRN protein: mechanism and relevance in clinical breast cancer

Werner syndrome protein (WRN) is a RecQ helicase that participates in DNA repair, genome stability and cellular senescence. The five human RecQ helicases, RECQL1, Bloom, WRN, RECQL4 and RECQL5 play critical roles in DNA repair and cell survival after treatment with the anticancer drug camptothecin (...

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Detalles Bibliográficos
Autores principales: Shamanna, Raghavendra A., Lu, Huiming, Croteau, Deborah L., Arora, Arvind, Agarwal, Devika, Ball, Graham, Aleskandarany, Mohammed A., Ellis, Ian O., Pommier, Yves, Madhusudan, Srinivasan, Bohr, Vilhelm A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924640/
https://www.ncbi.nlm.nih.gov/pubmed/26959889
http://dx.doi.org/10.18632/oncotarget.7906

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