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A multimodal assessment of balance in elderly and young adults
Falling is a significant health issue among elderly adults. Given the multifactorial nature of falls, effective balance and fall risk assessment must take into account factors from multiple sources. Here we investigate the relationship between fall risk and a diverse set of biochemical and biomechan...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924642/ https://www.ncbi.nlm.nih.gov/pubmed/26934319 http://dx.doi.org/10.18632/oncotarget.7758 |
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author | King, Gregory W. Abreu, Eduardo L. Cheng, An-Lin Chertoff, Keyna K. Brotto, Leticia Kelly, Patricia J. Brotto, Marco |
author_facet | King, Gregory W. Abreu, Eduardo L. Cheng, An-Lin Chertoff, Keyna K. Brotto, Leticia Kelly, Patricia J. Brotto, Marco |
author_sort | King, Gregory W. |
collection | PubMed |
description | Falling is a significant health issue among elderly adults. Given the multifactorial nature of falls, effective balance and fall risk assessment must take into account factors from multiple sources. Here we investigate the relationship between fall risk and a diverse set of biochemical and biomechanical variables including: skeletal muscle-specific troponin T (sTnT), maximal strength measures derived from isometric grip and leg extension tasks, and postural sway captured from a force platform during a quiet stance task. These measures were performed in eight young and eleven elderly adults, along with estimates of fall risk derived from the Tinetti Balance Assessment. We observed age-related effects in all measurements, including a trend toward increased sTnT levels, increased postural sway, reduced upper and lower extremity strength, and reduced balance scores. We observed a negative correlation between balance scores and sTnT levels, suggesting its use as a biomarker for fall risk. We observed a significant positive correlation between balance scores and strength measures, adding support to the notion that muscle strength plays a significant role in postural control. We observed a significant negative correlation between balance scores and postural sway, suggesting that fall risk is associated with more loosely controlled center of mass regulation. |
format | Online Article Text |
id | pubmed-4924642 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-49246422016-07-13 A multimodal assessment of balance in elderly and young adults King, Gregory W. Abreu, Eduardo L. Cheng, An-Lin Chertoff, Keyna K. Brotto, Leticia Kelly, Patricia J. Brotto, Marco Oncotarget Research Paper: Gerotarget (Focus on Aging) Falling is a significant health issue among elderly adults. Given the multifactorial nature of falls, effective balance and fall risk assessment must take into account factors from multiple sources. Here we investigate the relationship between fall risk and a diverse set of biochemical and biomechanical variables including: skeletal muscle-specific troponin T (sTnT), maximal strength measures derived from isometric grip and leg extension tasks, and postural sway captured from a force platform during a quiet stance task. These measures were performed in eight young and eleven elderly adults, along with estimates of fall risk derived from the Tinetti Balance Assessment. We observed age-related effects in all measurements, including a trend toward increased sTnT levels, increased postural sway, reduced upper and lower extremity strength, and reduced balance scores. We observed a negative correlation between balance scores and sTnT levels, suggesting its use as a biomarker for fall risk. We observed a significant positive correlation between balance scores and strength measures, adding support to the notion that muscle strength plays a significant role in postural control. We observed a significant negative correlation between balance scores and postural sway, suggesting that fall risk is associated with more loosely controlled center of mass regulation. Impact Journals LLC 2016-02-26 /pmc/articles/PMC4924642/ /pubmed/26934319 http://dx.doi.org/10.18632/oncotarget.7758 Text en Copyright: © 2016 King et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper: Gerotarget (Focus on Aging) King, Gregory W. Abreu, Eduardo L. Cheng, An-Lin Chertoff, Keyna K. Brotto, Leticia Kelly, Patricia J. Brotto, Marco A multimodal assessment of balance in elderly and young adults |
title | A multimodal assessment of balance in elderly and young adults |
title_full | A multimodal assessment of balance in elderly and young adults |
title_fullStr | A multimodal assessment of balance in elderly and young adults |
title_full_unstemmed | A multimodal assessment of balance in elderly and young adults |
title_short | A multimodal assessment of balance in elderly and young adults |
title_sort | multimodal assessment of balance in elderly and young adults |
topic | Research Paper: Gerotarget (Focus on Aging) |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924642/ https://www.ncbi.nlm.nih.gov/pubmed/26934319 http://dx.doi.org/10.18632/oncotarget.7758 |
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