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A multimodal assessment of balance in elderly and young adults

Falling is a significant health issue among elderly adults. Given the multifactorial nature of falls, effective balance and fall risk assessment must take into account factors from multiple sources. Here we investigate the relationship between fall risk and a diverse set of biochemical and biomechan...

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Autores principales: King, Gregory W., Abreu, Eduardo L., Cheng, An-Lin, Chertoff, Keyna K., Brotto, Leticia, Kelly, Patricia J., Brotto, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924642/
https://www.ncbi.nlm.nih.gov/pubmed/26934319
http://dx.doi.org/10.18632/oncotarget.7758
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author King, Gregory W.
Abreu, Eduardo L.
Cheng, An-Lin
Chertoff, Keyna K.
Brotto, Leticia
Kelly, Patricia J.
Brotto, Marco
author_facet King, Gregory W.
Abreu, Eduardo L.
Cheng, An-Lin
Chertoff, Keyna K.
Brotto, Leticia
Kelly, Patricia J.
Brotto, Marco
author_sort King, Gregory W.
collection PubMed
description Falling is a significant health issue among elderly adults. Given the multifactorial nature of falls, effective balance and fall risk assessment must take into account factors from multiple sources. Here we investigate the relationship between fall risk and a diverse set of biochemical and biomechanical variables including: skeletal muscle-specific troponin T (sTnT), maximal strength measures derived from isometric grip and leg extension tasks, and postural sway captured from a force platform during a quiet stance task. These measures were performed in eight young and eleven elderly adults, along with estimates of fall risk derived from the Tinetti Balance Assessment. We observed age-related effects in all measurements, including a trend toward increased sTnT levels, increased postural sway, reduced upper and lower extremity strength, and reduced balance scores. We observed a negative correlation between balance scores and sTnT levels, suggesting its use as a biomarker for fall risk. We observed a significant positive correlation between balance scores and strength measures, adding support to the notion that muscle strength plays a significant role in postural control. We observed a significant negative correlation between balance scores and postural sway, suggesting that fall risk is associated with more loosely controlled center of mass regulation.
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spelling pubmed-49246422016-07-13 A multimodal assessment of balance in elderly and young adults King, Gregory W. Abreu, Eduardo L. Cheng, An-Lin Chertoff, Keyna K. Brotto, Leticia Kelly, Patricia J. Brotto, Marco Oncotarget Research Paper: Gerotarget (Focus on Aging) Falling is a significant health issue among elderly adults. Given the multifactorial nature of falls, effective balance and fall risk assessment must take into account factors from multiple sources. Here we investigate the relationship between fall risk and a diverse set of biochemical and biomechanical variables including: skeletal muscle-specific troponin T (sTnT), maximal strength measures derived from isometric grip and leg extension tasks, and postural sway captured from a force platform during a quiet stance task. These measures were performed in eight young and eleven elderly adults, along with estimates of fall risk derived from the Tinetti Balance Assessment. We observed age-related effects in all measurements, including a trend toward increased sTnT levels, increased postural sway, reduced upper and lower extremity strength, and reduced balance scores. We observed a negative correlation between balance scores and sTnT levels, suggesting its use as a biomarker for fall risk. We observed a significant positive correlation between balance scores and strength measures, adding support to the notion that muscle strength plays a significant role in postural control. We observed a significant negative correlation between balance scores and postural sway, suggesting that fall risk is associated with more loosely controlled center of mass regulation. Impact Journals LLC 2016-02-26 /pmc/articles/PMC4924642/ /pubmed/26934319 http://dx.doi.org/10.18632/oncotarget.7758 Text en Copyright: © 2016 King et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper: Gerotarget (Focus on Aging)
King, Gregory W.
Abreu, Eduardo L.
Cheng, An-Lin
Chertoff, Keyna K.
Brotto, Leticia
Kelly, Patricia J.
Brotto, Marco
A multimodal assessment of balance in elderly and young adults
title A multimodal assessment of balance in elderly and young adults
title_full A multimodal assessment of balance in elderly and young adults
title_fullStr A multimodal assessment of balance in elderly and young adults
title_full_unstemmed A multimodal assessment of balance in elderly and young adults
title_short A multimodal assessment of balance in elderly and young adults
title_sort multimodal assessment of balance in elderly and young adults
topic Research Paper: Gerotarget (Focus on Aging)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924642/
https://www.ncbi.nlm.nih.gov/pubmed/26934319
http://dx.doi.org/10.18632/oncotarget.7758
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