Competing endogenous RNA networks in human cancer: hypothesis, validation, and perspectives

Non-coding RNAs represent a majority of the human transcriptome. However, less is known about the functions and regulatory mechanisms of most non-coding species. Moreover, little is known about the potential non-coding functions of coding RNAs. The competing endogenous RNAs (ceRNAs) hypothesis is pr...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Chao, Wu, Di, Gao, Lin, Liu, Xi, Jin, Yinji, Wang, Dong, Wang, Tianzhen, Li, Xiaobo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924655/
https://www.ncbi.nlm.nih.gov/pubmed/26872371
http://dx.doi.org/10.18632/oncotarget.7266
_version_ 1782439894868557824
author Yang, Chao
Wu, Di
Gao, Lin
Liu, Xi
Jin, Yinji
Wang, Dong
Wang, Tianzhen
Li, Xiaobo
author_facet Yang, Chao
Wu, Di
Gao, Lin
Liu, Xi
Jin, Yinji
Wang, Dong
Wang, Tianzhen
Li, Xiaobo
author_sort Yang, Chao
collection PubMed
description Non-coding RNAs represent a majority of the human transcriptome. However, less is known about the functions and regulatory mechanisms of most non-coding species. Moreover, little is known about the potential non-coding functions of coding RNAs. The competing endogenous RNAs (ceRNAs) hypothesis is proposed recently. This hypothesis describes potential communication networks among all transcript RNA species mediated by miRNAs and miRNA-recognizing elements (MREs) within RNA transcripts. Here we review the evolution of the ceRNA hypothesis, summarize the validation experiments and discusses the significance and perspectives of this hypothesis in human cancer.
format Online
Article
Text
id pubmed-4924655
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Impact Journals LLC
record_format MEDLINE/PubMed
spelling pubmed-49246552016-07-13 Competing endogenous RNA networks in human cancer: hypothesis, validation, and perspectives Yang, Chao Wu, Di Gao, Lin Liu, Xi Jin, Yinji Wang, Dong Wang, Tianzhen Li, Xiaobo Oncotarget Review Non-coding RNAs represent a majority of the human transcriptome. However, less is known about the functions and regulatory mechanisms of most non-coding species. Moreover, little is known about the potential non-coding functions of coding RNAs. The competing endogenous RNAs (ceRNAs) hypothesis is proposed recently. This hypothesis describes potential communication networks among all transcript RNA species mediated by miRNAs and miRNA-recognizing elements (MREs) within RNA transcripts. Here we review the evolution of the ceRNA hypothesis, summarize the validation experiments and discusses the significance and perspectives of this hypothesis in human cancer. Impact Journals LLC 2016-02-08 /pmc/articles/PMC4924655/ /pubmed/26872371 http://dx.doi.org/10.18632/oncotarget.7266 Text en Copyright: © 2016 Yang et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Yang, Chao
Wu, Di
Gao, Lin
Liu, Xi
Jin, Yinji
Wang, Dong
Wang, Tianzhen
Li, Xiaobo
Competing endogenous RNA networks in human cancer: hypothesis, validation, and perspectives
title Competing endogenous RNA networks in human cancer: hypothesis, validation, and perspectives
title_full Competing endogenous RNA networks in human cancer: hypothesis, validation, and perspectives
title_fullStr Competing endogenous RNA networks in human cancer: hypothesis, validation, and perspectives
title_full_unstemmed Competing endogenous RNA networks in human cancer: hypothesis, validation, and perspectives
title_short Competing endogenous RNA networks in human cancer: hypothesis, validation, and perspectives
title_sort competing endogenous rna networks in human cancer: hypothesis, validation, and perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924655/
https://www.ncbi.nlm.nih.gov/pubmed/26872371
http://dx.doi.org/10.18632/oncotarget.7266
work_keys_str_mv AT yangchao competingendogenousrnanetworksinhumancancerhypothesisvalidationandperspectives
AT wudi competingendogenousrnanetworksinhumancancerhypothesisvalidationandperspectives
AT gaolin competingendogenousrnanetworksinhumancancerhypothesisvalidationandperspectives
AT liuxi competingendogenousrnanetworksinhumancancerhypothesisvalidationandperspectives
AT jinyinji competingendogenousrnanetworksinhumancancerhypothesisvalidationandperspectives
AT wangdong competingendogenousrnanetworksinhumancancerhypothesisvalidationandperspectives
AT wangtianzhen competingendogenousrnanetworksinhumancancerhypothesisvalidationandperspectives
AT lixiaobo competingendogenousrnanetworksinhumancancerhypothesisvalidationandperspectives

Ejemplares similares