Hyperinsulinemia enhances interleukin-17-induced inflammation to promote prostate cancer development in obese mice through inhibiting glycogen synthase kinase 3-mediated phosphorylation and degradation of interleukin-17 receptor

Interleukin-17 (IL-17) plays important roles in inflammation, autoimmune diseases, and some cancers. Obese people are in a chronic inflammatory state with increased serum levels of IL-17, insulin, and insulin-like growth factor 1 (IGF1). How these factors contribute to the chronic inflammatory statu...

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Detalles Bibliográficos
Autores principales: Liu, Sen, Zhang, Qiuyang, Chen, Chong, Ge, Dongxia, Qu, Yine, Chen, Rongyi, Fan, Yi-Ming, Li, Nan, Tang, Wendell W., Zhang, Wensheng, Zhang, Kun, Wang, Alun R., Rowan, Brian G., Hill, Steven M., Sartor, Oliver, Abdel, Asim B., Myers, Leann, Lin, Qishan, You, Zongbing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924668/
https://www.ncbi.nlm.nih.gov/pubmed/26871944
http://dx.doi.org/10.18632/oncotarget.7296

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