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Predictive value of GGN and CAG repeat polymorphisms of androgen receptors in testicular cancer: a meta-analysis

The risk of testicular cancer (TC) is markedly increased in subjects with androgen insensitivity, and previous studies have proposed that GGN and CAG repeats in androgen receptors (AR) could be related to the risk of TC. To evaluate the association between the length of GGN and CAG repeats in AR and...

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Autores principales: Jiang, Weijun, Zhang, Jing, Zhou, Qing, Liu, Shuaimei, Ni, Mengxia, Zhu, Peiran, Wu, Qiuyue, Li, Weiwei, Zhang, Mingchao, Xia, Xinyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924676/
https://www.ncbi.nlm.nih.gov/pubmed/26885616
http://dx.doi.org/10.18632/oncotarget.7337
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author Jiang, Weijun
Zhang, Jing
Zhou, Qing
Liu, Shuaimei
Ni, Mengxia
Zhu, Peiran
Wu, Qiuyue
Li, Weiwei
Zhang, Mingchao
Xia, Xinyi
author_facet Jiang, Weijun
Zhang, Jing
Zhou, Qing
Liu, Shuaimei
Ni, Mengxia
Zhu, Peiran
Wu, Qiuyue
Li, Weiwei
Zhang, Mingchao
Xia, Xinyi
author_sort Jiang, Weijun
collection PubMed
description The risk of testicular cancer (TC) is markedly increased in subjects with androgen insensitivity, and previous studies have proposed that GGN and CAG repeats in androgen receptors (AR) could be related to the risk of TC. To evaluate the association between the length of GGN and CAG repeats in AR and TC, a meta-analysis involving 3255 TC cases and 2804 controls was performed. The results suggested that long GGN repeats are associated with an increased risk of TC compared with those < 23 [odds ratio (OR) = 1.22, 95% confidence interval (CI) = 1.05–1.41]; similarly, a subgroup analysis revealed that this association occurred in studies with case sizes > 200, and in the mid-latitude, and seminoma subgroups. The subgroup analysis based on populations, high-latitude, and seminomas/non-seminomas suggested that AR CAG repeat polymorphisms with > 25 and < 21 + > 25 repeats might confer a protective effect to the patients with TC (in the high-latitude subgroup analysis, for > 25 vs. 21–25: OR = 0.54, 95% CI = 0.41–0.70). In contrast, an increased risk of TC was observed for AR CAG repeat polymorphisms with > 25 and < 21 + > 25 repeats in the mid-latitude subgroup (for > 25 vs. 21–25: OR = 1.65, 95% CI = 1.09–2.50). In addition, no associations between the remaining subgroups and male infertility were observed. In short, this meta-analysis suggested that AR GGN and CAG repeat polymorphisms may be involved in the etiology of TC.
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spelling pubmed-49246762016-07-13 Predictive value of GGN and CAG repeat polymorphisms of androgen receptors in testicular cancer: a meta-analysis Jiang, Weijun Zhang, Jing Zhou, Qing Liu, Shuaimei Ni, Mengxia Zhu, Peiran Wu, Qiuyue Li, Weiwei Zhang, Mingchao Xia, Xinyi Oncotarget Research Paper The risk of testicular cancer (TC) is markedly increased in subjects with androgen insensitivity, and previous studies have proposed that GGN and CAG repeats in androgen receptors (AR) could be related to the risk of TC. To evaluate the association between the length of GGN and CAG repeats in AR and TC, a meta-analysis involving 3255 TC cases and 2804 controls was performed. The results suggested that long GGN repeats are associated with an increased risk of TC compared with those < 23 [odds ratio (OR) = 1.22, 95% confidence interval (CI) = 1.05–1.41]; similarly, a subgroup analysis revealed that this association occurred in studies with case sizes > 200, and in the mid-latitude, and seminoma subgroups. The subgroup analysis based on populations, high-latitude, and seminomas/non-seminomas suggested that AR CAG repeat polymorphisms with > 25 and < 21 + > 25 repeats might confer a protective effect to the patients with TC (in the high-latitude subgroup analysis, for > 25 vs. 21–25: OR = 0.54, 95% CI = 0.41–0.70). In contrast, an increased risk of TC was observed for AR CAG repeat polymorphisms with > 25 and < 21 + > 25 repeats in the mid-latitude subgroup (for > 25 vs. 21–25: OR = 1.65, 95% CI = 1.09–2.50). In addition, no associations between the remaining subgroups and male infertility were observed. In short, this meta-analysis suggested that AR GGN and CAG repeat polymorphisms may be involved in the etiology of TC. Impact Journals LLC 2016-02-12 /pmc/articles/PMC4924676/ /pubmed/26885616 http://dx.doi.org/10.18632/oncotarget.7337 Text en Copyright: © 2016 Jiang et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Jiang, Weijun
Zhang, Jing
Zhou, Qing
Liu, Shuaimei
Ni, Mengxia
Zhu, Peiran
Wu, Qiuyue
Li, Weiwei
Zhang, Mingchao
Xia, Xinyi
Predictive value of GGN and CAG repeat polymorphisms of androgen receptors in testicular cancer: a meta-analysis
title Predictive value of GGN and CAG repeat polymorphisms of androgen receptors in testicular cancer: a meta-analysis
title_full Predictive value of GGN and CAG repeat polymorphisms of androgen receptors in testicular cancer: a meta-analysis
title_fullStr Predictive value of GGN and CAG repeat polymorphisms of androgen receptors in testicular cancer: a meta-analysis
title_full_unstemmed Predictive value of GGN and CAG repeat polymorphisms of androgen receptors in testicular cancer: a meta-analysis
title_short Predictive value of GGN and CAG repeat polymorphisms of androgen receptors in testicular cancer: a meta-analysis
title_sort predictive value of ggn and cag repeat polymorphisms of androgen receptors in testicular cancer: a meta-analysis
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924676/
https://www.ncbi.nlm.nih.gov/pubmed/26885616
http://dx.doi.org/10.18632/oncotarget.7337
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