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Predictive value of GGN and CAG repeat polymorphisms of androgen receptors in testicular cancer: a meta-analysis
The risk of testicular cancer (TC) is markedly increased in subjects with androgen insensitivity, and previous studies have proposed that GGN and CAG repeats in androgen receptors (AR) could be related to the risk of TC. To evaluate the association between the length of GGN and CAG repeats in AR and...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924676/ https://www.ncbi.nlm.nih.gov/pubmed/26885616 http://dx.doi.org/10.18632/oncotarget.7337 |
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author | Jiang, Weijun Zhang, Jing Zhou, Qing Liu, Shuaimei Ni, Mengxia Zhu, Peiran Wu, Qiuyue Li, Weiwei Zhang, Mingchao Xia, Xinyi |
author_facet | Jiang, Weijun Zhang, Jing Zhou, Qing Liu, Shuaimei Ni, Mengxia Zhu, Peiran Wu, Qiuyue Li, Weiwei Zhang, Mingchao Xia, Xinyi |
author_sort | Jiang, Weijun |
collection | PubMed |
description | The risk of testicular cancer (TC) is markedly increased in subjects with androgen insensitivity, and previous studies have proposed that GGN and CAG repeats in androgen receptors (AR) could be related to the risk of TC. To evaluate the association between the length of GGN and CAG repeats in AR and TC, a meta-analysis involving 3255 TC cases and 2804 controls was performed. The results suggested that long GGN repeats are associated with an increased risk of TC compared with those < 23 [odds ratio (OR) = 1.22, 95% confidence interval (CI) = 1.05–1.41]; similarly, a subgroup analysis revealed that this association occurred in studies with case sizes > 200, and in the mid-latitude, and seminoma subgroups. The subgroup analysis based on populations, high-latitude, and seminomas/non-seminomas suggested that AR CAG repeat polymorphisms with > 25 and < 21 + > 25 repeats might confer a protective effect to the patients with TC (in the high-latitude subgroup analysis, for > 25 vs. 21–25: OR = 0.54, 95% CI = 0.41–0.70). In contrast, an increased risk of TC was observed for AR CAG repeat polymorphisms with > 25 and < 21 + > 25 repeats in the mid-latitude subgroup (for > 25 vs. 21–25: OR = 1.65, 95% CI = 1.09–2.50). In addition, no associations between the remaining subgroups and male infertility were observed. In short, this meta-analysis suggested that AR GGN and CAG repeat polymorphisms may be involved in the etiology of TC. |
format | Online Article Text |
id | pubmed-4924676 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-49246762016-07-13 Predictive value of GGN and CAG repeat polymorphisms of androgen receptors in testicular cancer: a meta-analysis Jiang, Weijun Zhang, Jing Zhou, Qing Liu, Shuaimei Ni, Mengxia Zhu, Peiran Wu, Qiuyue Li, Weiwei Zhang, Mingchao Xia, Xinyi Oncotarget Research Paper The risk of testicular cancer (TC) is markedly increased in subjects with androgen insensitivity, and previous studies have proposed that GGN and CAG repeats in androgen receptors (AR) could be related to the risk of TC. To evaluate the association between the length of GGN and CAG repeats in AR and TC, a meta-analysis involving 3255 TC cases and 2804 controls was performed. The results suggested that long GGN repeats are associated with an increased risk of TC compared with those < 23 [odds ratio (OR) = 1.22, 95% confidence interval (CI) = 1.05–1.41]; similarly, a subgroup analysis revealed that this association occurred in studies with case sizes > 200, and in the mid-latitude, and seminoma subgroups. The subgroup analysis based on populations, high-latitude, and seminomas/non-seminomas suggested that AR CAG repeat polymorphisms with > 25 and < 21 + > 25 repeats might confer a protective effect to the patients with TC (in the high-latitude subgroup analysis, for > 25 vs. 21–25: OR = 0.54, 95% CI = 0.41–0.70). In contrast, an increased risk of TC was observed for AR CAG repeat polymorphisms with > 25 and < 21 + > 25 repeats in the mid-latitude subgroup (for > 25 vs. 21–25: OR = 1.65, 95% CI = 1.09–2.50). In addition, no associations between the remaining subgroups and male infertility were observed. In short, this meta-analysis suggested that AR GGN and CAG repeat polymorphisms may be involved in the etiology of TC. Impact Journals LLC 2016-02-12 /pmc/articles/PMC4924676/ /pubmed/26885616 http://dx.doi.org/10.18632/oncotarget.7337 Text en Copyright: © 2016 Jiang et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Jiang, Weijun Zhang, Jing Zhou, Qing Liu, Shuaimei Ni, Mengxia Zhu, Peiran Wu, Qiuyue Li, Weiwei Zhang, Mingchao Xia, Xinyi Predictive value of GGN and CAG repeat polymorphisms of androgen receptors in testicular cancer: a meta-analysis |
title | Predictive value of GGN and CAG repeat polymorphisms of androgen receptors in testicular cancer: a meta-analysis |
title_full | Predictive value of GGN and CAG repeat polymorphisms of androgen receptors in testicular cancer: a meta-analysis |
title_fullStr | Predictive value of GGN and CAG repeat polymorphisms of androgen receptors in testicular cancer: a meta-analysis |
title_full_unstemmed | Predictive value of GGN and CAG repeat polymorphisms of androgen receptors in testicular cancer: a meta-analysis |
title_short | Predictive value of GGN and CAG repeat polymorphisms of androgen receptors in testicular cancer: a meta-analysis |
title_sort | predictive value of ggn and cag repeat polymorphisms of androgen receptors in testicular cancer: a meta-analysis |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924676/ https://www.ncbi.nlm.nih.gov/pubmed/26885616 http://dx.doi.org/10.18632/oncotarget.7337 |
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