Cargando…

Inhibition of the p53/hDM2 protein-protein interaction by cyclometallated iridium(III) compounds

Inactivation of the p53 transcription factor by mutation or other mechanisms is a frequent event in tumorigenesis. One of the major endogenous negative regulators of p53 in humans is hDM2, a ubiquitin E3 ligase that binds to p53 causing proteasomal p53 degradation. In this work, a library of organom...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Li-Juan, He, Bingyong, Miles, Jennifer A., Wang, Wanhe, Mao, Zhifeng, Che, Weng Ian, Lu, Jin-Jian, Chen, Xiu-Ping, Wilson, Andrew J., Ma, Dik-Lung, Leung, Chung-Hang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924691/ https://www.ncbi.nlm.nih.gov/pubmed/26883110 http://dx.doi.org/10.18632/oncotarget.7369

Ejemplares similares

Luminescent chemosensors by using cyclometalated iridium(iii) complexes and their applications
por: Ma, Dik-Lung, et al.
Publicado: (2017)

A cyclometalated iridium(III) complex used as a conductor for the electrochemical sensing of IFN-γ
por: Miao, Xiangmin, et al.
Publicado: (2017)

Phosphorescent Imaging of Living Cells Using a Cyclometalated Iridium(III) Complex
por: Ma, Dik-Lung, et al.
Publicado: (2013)

Luminescent Iridium(III) Chemosensor for Tandem Detection of F(–) and Al(3+)
por: Liu, Jin-Biao, et al.
Publicado: (2017)

Oncosis-inducing cyclometalated iridium(iii) complexes
por: Guan, Ruilin, et al.
Publicado: (2018)

Facial Preparation of Cyclometalated Iridium (III) Nanowires as Highly Efficient Electrochemiluminescence Luminophores for Biosensing
por: Huang, Yueyue, et al.
Publicado: (2023)

Development of a luminescent G-quadruplex-selective iridium(III) complex for the label-free detection of adenosine
por: Lu, Lihua, et al.
Publicado: (2016)

Oligobenzamide proteomimetic inhibitors of the p53–hDM2 protein–protein interaction
por: Plante, Jeffrey P., et al.
Publicado: (2009)

A long-lived peptide-conjugated iridium(iii) complex as a luminescent probe and inhibitor of the cell migration mediator, formyl peptide receptor 2
por: Vellaisamy, Kasipandi, et al.
Publicado: (2018)

Activity‐Directed Synthesis of Inhibitors of the p53/hDM2 Protein–Protein Interaction
por: Green, Adam I., et al.
Publicado: (2020)

Inhibition of autophagic flux by cyclometalated iridium(iii) complexes through anion transportation
por: Chen, Mu-He, et al.
Publicado: (2019)

Iridium(III) Complexes Targeting Apoptotic Cell Death in Cancer Cells
por: Ma, Dik-Lung, et al.
Publicado: (2019)

Cyclometalated iridium(III) chelates—a new exceptional class of the electrochemiluminescent luminophores
por: Kapturkiewicz, Andrzej
Publicado: (2016)

Ester-Modified Cyclometalated Iridium(III) Complexes as Mitochondria-Targeting Anticancer Agents
por: Wang, Fang-Xin, et al.
Publicado: (2016)

Cyclometalated iridium(III) complexes combined with fluconazole: antifungal activity against resistant C. albicans
por: Lu, Jun-Jian, et al.
Publicado: (2023)

A bioactive ligand-conjugated iridium(III) metal-based complex as a Keap1–Nrf2 protein-protein interaction inhibitor against acetaminophen-induced acute liver injury
por: Li, Guodong, et al.
Publicado: (2021)

An iridium(iii)-based irreversible protein–protein interaction inhibitor of BRD4 as a potent anticancer agent
por: Zhong, Hai-Jing, et al.
Publicado: (2015)

Targeting cancer cell metabolism with mitochondria-immobilized phosphorescent cyclometalated iridium(iii) complexes
por: Cao, Jian-Jun, et al.
Publicado: (2017)

Cobalt(III) Carbene Complex with an Electronic Excited-State Structure Similar to Cyclometalated Iridium(III) Compounds
por: Sinha, Narayan, et al.
Publicado: (2022)

Cyclometalated iridium–BODIPY ratiometric O(2) sensors
por: Choung, Ku Sun, et al.
Publicado: (2019)

Inhibition of the Ras/Raf interaction and repression of renal cancer xenografts in vivo by an enantiomeric iridium(iii) metal-based compound
por: Liu, Li-Juan, et al.
Publicado: (2017)

A novel dinuclear iridium(III) complex as a G-quadruplex-selective probe for the luminescent switch-on detection of transcription factor HIF-1α
por: Lu, Lihua, et al.
Publicado: (2016)

Cyclometalated iridium(iii) complexes as lysosome-targeted photodynamic anticancer and real-time tracking agents
por: He, Liang, et al.
Publicado: (2015)

Water-Soluble Tris(cyclometalated) Iridium(III) Complexes for Aqueous Electron and Energy Transfer Photochemistry
por: Schreier, Mirjam R., et al.
Publicado: (2022)

Bis-cyclometalated iridium(iii) complexes with terpyridine analogues: syntheses, structures, spectroscopy and computational studies
por: Otaif, Haleema Y., et al.
Publicado: (2021)

Lysosomal Targeted Cyclometallic Iridium(Ⅲ) Salicylaldehyde-Coumarin Schiff Base Complexes and Anticancer Application
por: Xu, Ruixi, et al.
Publicado: (2022)

Ligand effect of cyclometallated iridium(iii) complexes on N-alkylation of amines in hydrogen borrowing reactions
por: Chen, Yi-Sheng, et al.
Publicado: (2023)

Inhibition of Beta-Amyloid Fibrillation by Luminescent Iridium(III) Complex Probes
por: Lu, Lihua, et al.
Publicado: (2015)

Identification of an iridium(III) complex with anti-bacterial and anti-cancer activity
por: Lu, Lihua, et al.
Publicado: (2015)

Mixed-carbene cyclometalated iridium complexes with saturated blue luminescence
por: Na, Hanah, et al.
Publicado: (2019)

An Aldol Reaction-Based Iridium(III) Chemosensor for the Visualization of Proline in Living Cells
por: Liu, Jin-Biao, et al.
Publicado: (2016)

Cyclometalated Iridium(III) Complexes as AIE Phosphorescent Probes for Real-Time Monitoring of Mitophagy in Living Cells
por: Jin, Chengzhi, et al.
Publicado: (2016)

Tuning the Emission of Cationic Iridium (III) Complexes Towards the Red Through Methoxy Substitution of the Cyclometalating Ligand
por: Hasan, Kamrul, et al.
Publicado: (2015)

Cationic Heteroleptic Cyclometalated Iridium(III) Complexes Containing Phenyl-Triazole and Triazole-Pyridine Clicked Ligands
por: Felici, Marco, et al.
Publicado: (2010)

Cyclometalated Iridium(III) Complexes Incorporating Aromatic Phosphonate Ligands: Syntheses, Structures, and Tunable Optical Properties
por: Zeng, Dai, et al.
Publicado: (2019)

4-Phenyl-1,2,3-triazoles as Versatile Ligands for Cationic Cyclometalated Iridium(III) Complexes
por: Di Girolamo, Alessandro, et al.
Publicado: (2022)

A colorimetric chemosensor for Cu(2+) ion detection based on an iridium(III) complex
por: Wang, Modi, et al.
Publicado: (2014)

Luminescent turn-on detection of Hg(II) via the quenching of an iridium(III) complex by Hg(II)-mediated silver nanoparticles
por: Liu, Jinshui, et al.
Publicado: (2017)

The design and development of covalent protein-protein interaction inhibitors for cancer treatment
por: Cheng, Sha-Sha, et al.
Publicado: (2020)

Application of iridium(III) complex in label-free and non-enzymatic electrochemical detection of hydrogen peroxide based on a novel “on-off-on” switch platform
por: Miao, Xiangmin, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_nd3resa42o90pddmji5g133p00