Analogs of the novel phytohormone, strigolactone, trigger apoptosis and synergize with PARP inhibitors by inducing DNA damage and inhibiting DNA repair

Strigolactones are a novel class of plant hormones produced in roots that regulate shoot and root development. We previously reported that strigolactone analogs (SLs) induce G2/M cell cycle arrest and apoptosis in a variety of human cancer cells and inhibit tumor growth of human breast cancer xenogr...

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Detalles Bibliográficos
Autores principales: Croglio, Michael P., Haake, Jefferson M., Ryan, Colin P., Wang, Victor S., Lapier, Jennifer, Schlarbaum, Jamie P., Dayani, Yaron, Artuso, Emma, Prandi, Cristina, Koltai, Hinanit, Agama, Keli, Pommier, Yves, Chen, Yu, Tricoli, Lucas, LaRocque, Jeannine R., Albanese, Christopher, Yarden, Ronit I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924693/
https://www.ncbi.nlm.nih.gov/pubmed/26910887
http://dx.doi.org/10.18632/oncotarget.7414

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