Glucose-regulated protein 94 deficiency induces squamous cell metaplasia and suppresses PTEN-null driven endometrial epithelial tumor development

Endometrial carcinoma is the most prevalent gynecologic cancer in the United States. The tumor suppressor gene Pten (phosphatase and tensin homolog) is commonly mutated in the more common type 1 (endometrioid) subtype. The glucose-regulated protein 94 (GRP94) is emerging as a novel regulator for can...

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Detalles Bibliográficos
Autores principales: Shen, Jieli, Yao, Lijing, Lin, Yvonne G., DeMayo, Francesco J., Lydon, John P., Dubeau, Louis, Lee, Amy S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924759/
https://www.ncbi.nlm.nih.gov/pubmed/26910913
http://dx.doi.org/10.18632/oncotarget.7450

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