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Effect of alpha-lipoic acid on radiation-induced small intestine injury in mice
PURPOSE: Radiation therapy is a highly effective treatment for patients with solid tumors. However, it can cause damage and inflammation in normal tissues. Here, we investigated the effects of alpha-lipoic acid (ALA) as radioprotection agent for the small intestine in a mouse model. MATERIALS AND ME...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924773/ https://www.ncbi.nlm.nih.gov/pubmed/26943777 http://dx.doi.org/10.18632/oncotarget.7874 |
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author | Jeong, Bae Kwon Song, Jin Ho Jeong, Hojin Choi, Hoon Sik Jung, Jung Hwa Hahm, Jong Ryeal Woo, Seung Hoon Jung, Myeong Hee Choi, Bong-Hoi Kim, Jin Hyun Kang, Ki Mun |
author_facet | Jeong, Bae Kwon Song, Jin Ho Jeong, Hojin Choi, Hoon Sik Jung, Jung Hwa Hahm, Jong Ryeal Woo, Seung Hoon Jung, Myeong Hee Choi, Bong-Hoi Kim, Jin Hyun Kang, Ki Mun |
author_sort | Jeong, Bae Kwon |
collection | PubMed |
description | PURPOSE: Radiation therapy is a highly effective treatment for patients with solid tumors. However, it can cause damage and inflammation in normal tissues. Here, we investigated the effects of alpha-lipoic acid (ALA) as radioprotection agent for the small intestine in a mouse model. MATERIALS AND METHODS: Whole abdomen was evenly irradiated with total a dose of 15 Gy. Mice were treated with either ALA (100 mg/kg, intraperitoneal injection [i.p.]) or saline (equal volume, i.p.) the prior to radiation as 100 mg/kg/day for 3 days. Body weight, food intake, histopathology, and biochemical parameters were evaluated. RESULTS: Significant differences in body weight and food intake were observed between the radiation (RT) and ALA + RT groups. Moreover, the number of crypt cells was higher in the ALA + RT group. Inflammation was decreased and recovery time was shortened in the ALA + RT group compared with the RT group. The levels of inflammation-related factors (i.e., phosphorylated nuclear factor kappa B and matrix metalloproteinase-9) and mitogen-activated protein kinases were significantly decreased in the ALA + RT group compared with those in the RT group. CONCLUSIONS: ALA treatment prior to radiation decreases the severity and duration of radiation-induced enteritis by reducing inflammation, oxidative stress, and cell death. |
format | Online Article Text |
id | pubmed-4924773 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-49247732016-07-13 Effect of alpha-lipoic acid on radiation-induced small intestine injury in mice Jeong, Bae Kwon Song, Jin Ho Jeong, Hojin Choi, Hoon Sik Jung, Jung Hwa Hahm, Jong Ryeal Woo, Seung Hoon Jung, Myeong Hee Choi, Bong-Hoi Kim, Jin Hyun Kang, Ki Mun Oncotarget Research Paper PURPOSE: Radiation therapy is a highly effective treatment for patients with solid tumors. However, it can cause damage and inflammation in normal tissues. Here, we investigated the effects of alpha-lipoic acid (ALA) as radioprotection agent for the small intestine in a mouse model. MATERIALS AND METHODS: Whole abdomen was evenly irradiated with total a dose of 15 Gy. Mice were treated with either ALA (100 mg/kg, intraperitoneal injection [i.p.]) or saline (equal volume, i.p.) the prior to radiation as 100 mg/kg/day for 3 days. Body weight, food intake, histopathology, and biochemical parameters were evaluated. RESULTS: Significant differences in body weight and food intake were observed between the radiation (RT) and ALA + RT groups. Moreover, the number of crypt cells was higher in the ALA + RT group. Inflammation was decreased and recovery time was shortened in the ALA + RT group compared with the RT group. The levels of inflammation-related factors (i.e., phosphorylated nuclear factor kappa B and matrix metalloproteinase-9) and mitogen-activated protein kinases were significantly decreased in the ALA + RT group compared with those in the RT group. CONCLUSIONS: ALA treatment prior to radiation decreases the severity and duration of radiation-induced enteritis by reducing inflammation, oxidative stress, and cell death. Impact Journals LLC 2016-03-03 /pmc/articles/PMC4924773/ /pubmed/26943777 http://dx.doi.org/10.18632/oncotarget.7874 Text en Copyright: © 2016 Jeong et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Jeong, Bae Kwon Song, Jin Ho Jeong, Hojin Choi, Hoon Sik Jung, Jung Hwa Hahm, Jong Ryeal Woo, Seung Hoon Jung, Myeong Hee Choi, Bong-Hoi Kim, Jin Hyun Kang, Ki Mun Effect of alpha-lipoic acid on radiation-induced small intestine injury in mice |
title | Effect of alpha-lipoic acid on radiation-induced small intestine injury in mice |
title_full | Effect of alpha-lipoic acid on radiation-induced small intestine injury in mice |
title_fullStr | Effect of alpha-lipoic acid on radiation-induced small intestine injury in mice |
title_full_unstemmed | Effect of alpha-lipoic acid on radiation-induced small intestine injury in mice |
title_short | Effect of alpha-lipoic acid on radiation-induced small intestine injury in mice |
title_sort | effect of alpha-lipoic acid on radiation-induced small intestine injury in mice |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924773/ https://www.ncbi.nlm.nih.gov/pubmed/26943777 http://dx.doi.org/10.18632/oncotarget.7874 |
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