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Antibody-Mediated Neutralization of the Exotoxin Mycolactone, the Main Virulence Factor Produced by Mycobacterium ulcerans

BACKGROUND: Mycolactone, the macrolide exotoxin produced by Mycobacterium ulcerans, causes extensive tissue destruction by inducing apoptosis of host cells. In this study, we aimed at the production of antibodies that could neutralize the cytotoxic activities of mycolactone. METHODOLOGY/PRINCIPAL FI...

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Detalles Bibliográficos
Autores principales:	Dangy, Jean-Pierre, Scherr, Nicole, Gersbach, Philipp, Hug, Melanie N., Bieri, Raphael, Bomio, Claudio, Li, Jun, Huber, Sylwia, Altmann, Karl-Heinz, Pluschke, Gerd
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924874/ https://www.ncbi.nlm.nih.gov/pubmed/27351976 http://dx.doi.org/10.1371/journal.pntd.0004808

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