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AXL receptor tyrosine kinase is required for T cell priming and antiviral immunity
The receptor tyrosine kinase (RTK) AXL is induced in response to type I interferons (IFNs) and limits their production through a negative feedback loop. Enhanced production of type I IFNs in Axl(-/-)dendritic cells (DCs) in vitro have led to speculation that inhibition of AXL would promote antiviral...
Autores principales: | Schmid, Edward T, Pang, Iris K, Carrera Silva, Eugenio A, Bosurgi, Lidia, Miner, Jonathan J, Diamond, Michael S, Iwasaki, Akiko, Rothlin, Carla V |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924996/ https://www.ncbi.nlm.nih.gov/pubmed/27350258 http://dx.doi.org/10.7554/eLife.12414 |
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