The Polycystin complex mediates WNT/Ca(2+) signaling

WNT ligands induce Ca(2+) signaling on target cells. PKD1 (Polycystin 1) is considered an orphan, atypical G protein coupled receptor complexed with TRPP2 (Polycystin 2 or PKD2), a Ca(2+)-permeable ion channel. Inactivating mutations in their genes cause autosomal dominant polycystic kidney disease...

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Detalles Bibliográficos
Autores principales: Kim, Seokho, Nie, Hongguang, Nesin, Vasyl, Tran, Uyen, Outeda, Patricia, Bai, Chang-Xi, Keeling, Jacob, Maskey, Dipak, Watnick, Terry, Wessely, Oliver, Tsiokas, Leonidas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4925210/
https://www.ncbi.nlm.nih.gov/pubmed/27214281
http://dx.doi.org/10.1038/ncb3363

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