A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases

There is growing evidence of shared risk alleles between complex traits (pleiotropy), including autoimmune and neuropsychiatric diseases. This might be due to sharing between all individuals (whole-group pleiotropy), or a subset of individuals within a genetically heterogeneous cohort (subgroup hete...

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Detalles Bibliográficos
Autores principales: Han, Buhm, Pouget, Jennie G., Slowikowski, Kamil, Stahl, Eli, Lee, Cue Hyunkyu, Diogo, Dorothee, Hu, Xinli, Park, Yu Rang, Kim, Eunji, Gregersen, Peter K., Dahlqvist, Solbritt Rantapää, Worthington, Jane, Martin, Javier, Eyre, Steve, Klareskog, Lars, Huizinga, Tom, Chen, Wei-Min, Onengut-Gumuscu, Suna, Rich, Stephen S., Wray, Naomi R., Raychaudhuri, Soumya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4925284/
https://www.ncbi.nlm.nih.gov/pubmed/27182969
http://dx.doi.org/10.1038/ng.3572

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4925284/
https://www.ncbi.nlm.nih.gov/pubmed/27182969
http://dx.doi.org/10.1038/ng.3572

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