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Protein Kinase A and Anxiety-Related Behaviors: A Mini-Review

This review focuses on the anxiety related to cyclic AMP/protein kinase A (PKA) signaling pathway that regulates stress responses. PKA regulates an array of diverse signals that interact with various neurotransmitter systems associated with alertness, mood, and acute and social anxiety-like states....

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Autores principales: Keil, Margaret F., Briassoulis, George, Stratakis, Constantine A., Wu, T. John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4925668/
https://www.ncbi.nlm.nih.gov/pubmed/27445986
http://dx.doi.org/10.3389/fendo.2016.00083
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author Keil, Margaret F.
Briassoulis, George
Stratakis, Constantine A.
Wu, T. John
author_facet Keil, Margaret F.
Briassoulis, George
Stratakis, Constantine A.
Wu, T. John
author_sort Keil, Margaret F.
collection PubMed
description This review focuses on the anxiety related to cyclic AMP/protein kinase A (PKA) signaling pathway that regulates stress responses. PKA regulates an array of diverse signals that interact with various neurotransmitter systems associated with alertness, mood, and acute and social anxiety-like states. Recent mouse studies support the involvement of the PKA pathway in common neuropsychiatric disorders characterized by heightened activation of the amygdala. The amygdala is critical for adaptive responses leading to fear learning and aberrant fear memory and its heightened activation is widely thought to underpin various anxiety disorders. Stress-induced plasticity within the amygdala is involved in the transition from normal vigilance responses to emotional reactivity, fear over-generalization, and deficits in fear inhibition resulting in pathological anxiety and conditions, such as panic and depression. Human studies of PKA signaling defects also report an increased incidence of psychiatric disorders, including anxiety, depression, bipolar disorder, learning disorders, and attention deficit hyperactivity disorder. We speculate that the PKA system is uniquely suited for selective, molecularly targeted intervention that may be proven effective in anxiolytic therapy.
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spelling pubmed-49256682016-07-21 Protein Kinase A and Anxiety-Related Behaviors: A Mini-Review Keil, Margaret F. Briassoulis, George Stratakis, Constantine A. Wu, T. John Front Endocrinol (Lausanne) Endocrinology This review focuses on the anxiety related to cyclic AMP/protein kinase A (PKA) signaling pathway that regulates stress responses. PKA regulates an array of diverse signals that interact with various neurotransmitter systems associated with alertness, mood, and acute and social anxiety-like states. Recent mouse studies support the involvement of the PKA pathway in common neuropsychiatric disorders characterized by heightened activation of the amygdala. The amygdala is critical for adaptive responses leading to fear learning and aberrant fear memory and its heightened activation is widely thought to underpin various anxiety disorders. Stress-induced plasticity within the amygdala is involved in the transition from normal vigilance responses to emotional reactivity, fear over-generalization, and deficits in fear inhibition resulting in pathological anxiety and conditions, such as panic and depression. Human studies of PKA signaling defects also report an increased incidence of psychiatric disorders, including anxiety, depression, bipolar disorder, learning disorders, and attention deficit hyperactivity disorder. We speculate that the PKA system is uniquely suited for selective, molecularly targeted intervention that may be proven effective in anxiolytic therapy. Frontiers Media S.A. 2016-06-29 /pmc/articles/PMC4925668/ /pubmed/27445986 http://dx.doi.org/10.3389/fendo.2016.00083 Text en Copyright © 2016 Keil, Briassoulis, Stratakis and Wu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Keil, Margaret F.
Briassoulis, George
Stratakis, Constantine A.
Wu, T. John
Protein Kinase A and Anxiety-Related Behaviors: A Mini-Review
title Protein Kinase A and Anxiety-Related Behaviors: A Mini-Review
title_full Protein Kinase A and Anxiety-Related Behaviors: A Mini-Review
title_fullStr Protein Kinase A and Anxiety-Related Behaviors: A Mini-Review
title_full_unstemmed Protein Kinase A and Anxiety-Related Behaviors: A Mini-Review
title_short Protein Kinase A and Anxiety-Related Behaviors: A Mini-Review
title_sort protein kinase a and anxiety-related behaviors: a mini-review
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4925668/
https://www.ncbi.nlm.nih.gov/pubmed/27445986
http://dx.doi.org/10.3389/fendo.2016.00083
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