Recurrence of progressive multifocal leukoencephalopathy despite immune recovery in two HIV seropositive individuals

We present two cases of recurrent progressive multifocal leukoencephalopathy (PML) in patients with long standing virally suppressed human immunodeficiency virus (HIV) and normal CD4+ T cell count who were taking stable regimens of highly active antiretroviral therapy (HAART). This has significant i...

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Detalles Bibliográficos
Autores principales: Crossley, Kate M., Agnihotri, Shruti, Chaganti, Joga, Rodriguez, Michael L., McNally, Leon Patrick, Venna, Nagagopal, Turbett, Sarah E., Gutman, Matthew, Morey, Adrienne, Koralnik, Igor J., Brew, Bruce J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4925684/
https://www.ncbi.nlm.nih.gov/pubmed/26727910
http://dx.doi.org/10.1007/s13365-015-0419-y
Descripción
Sumario:We present two cases of recurrent progressive multifocal leukoencephalopathy (PML) in patients with long standing virally suppressed human immunodeficiency virus (HIV) and normal CD4+ T cell count who were taking stable regimens of highly active antiretroviral therapy (HAART). This has significant implications for other patients with a past history of PML, not just those with HIV but also those on medications such as natalizumab or fumarates.

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