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Differences in the timing and magnitude of Pkd1 gene deletion determine the severity of polycystic kidney disease in an orthologous mouse model of ADPKD

Development of a disease‐modifying therapy to treat autosomal dominant polycystic kidney disease (ADPKD) requires well‐characterized preclinical models that accurately reflect the pathology and biochemical changes associated with the disease. Using a Pkd1 conditional knockout mouse, we demonstrate t...

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Detalles Bibliográficos
Autores principales:	Rogers, Kelly A., Moreno, Sarah E., Smith, Laurie A., Husson, Hervé, Bukanov, Nikolay O., Ledbetter, Steven R., Budman, Yeva, Lu, Yuefeng, Wang, Bing, Ibraghimov‐Beskrovnaya, Oxana, Natoli, Thomas A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926022/ https://www.ncbi.nlm.nih.gov/pubmed/27356569 http://dx.doi.org/10.14814/phy2.12846

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