Cargando…

Deep sequencing and in silico analyses identify MYB-regulated gene networks and signaling pathways in pancreatic cancer

We have recently demonstrated that the transcription factor MYB can modulate several cancer-associated phenotypes in pancreatic cancer. In order to understand the molecular basis of these MYB-associated changes, we conducted deep-sequencing of transcriptome of MYB-overexpressing and -silenced pancre...

Descripción completa

Detalles Bibliográficos
Autores principales:	Azim, Shafquat, Zubair, Haseeb, Srivastava, Sanjeev K., Bhardwaj, Arun, Zubair, Asif, Ahmad, Aamir, Singh, Seema, Khushman, Moh’d., Singh, Ajay P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926062/ https://www.ncbi.nlm.nih.gov/pubmed/27354262 http://dx.doi.org/10.1038/srep28446

Ejemplares similares

Molecular Drivers of Pancreatic Cancer Pathogenesis: Looking Inward to Move Forward
por: Khan, Mohammad Aslam, et al.
Publicado: (2017)

MYB is a novel regulator of pancreatic tumour growth and metastasis
por: Srivastava, Sanjeev K, et al.
Publicado: (2015)

Exosomes confer chemoresistance to pancreatic cancer cells by promoting ROS detoxification and miR-155-mediated suppression of key gemcitabine-metabolising enzyme, DCK
por: Patel, Girijesh Kumar, et al.
Publicado: (2017)

Comparative analysis of exosome isolation methods using culture supernatant for optimum yield, purity and downstream applications
por: Patel, Girijesh Kumar, et al.
Publicado: (2019)

Cancer Chemoprevention by Phytochemicals: Nature’s Healing Touch
por: Zubair, Haseeb, et al.
Publicado: (2017)

Biphasic transcriptional and posttranscriptional regulation of MYB by androgen signaling mediates its growth control in prostate cancer
por: Acharya, Srijan, et al.
Publicado: (2022)

Gemcitabine triggers angiogenesis-promoting molecular signals in pancreatic cancer cells: Therapeutic implications
por: Khan, Mohammad Aslam, et al.
Publicado: (2015)

Mobilization of Intracellular Copper by Gossypol and Apogossypolone Leads to Reactive Oxygen Species-Mediated Cell Death: Putative Anticancer Mechanism
por: Zubair, Haseeb, et al.
Publicado: (2016)

Comprehensive Analysis of Expression, Clinicopathological Association and Potential Prognostic Significance of RABs in Pancreatic Cancer
por: Anand, Shashi, et al.
Publicado: (2020)

Exosomal Formulation Escalates Cellular Uptake of Honokiol Leading to the Enhancement of Its Antitumor Efficacy
por: Kanchanapally, Rajashekhar, et al.
Publicado: (2020)

Resistin Induces LIN28A-Mediated Let-7a Repression in Breast Cancer Cells Leading to IL-6 and STAT3 Upregulation
por: Deshmukh, Sachin Kumar, et al.
Publicado: (2021)

Revisiting the Clinical Importance of DPYD*9A (c.85T>C) Variant of Dihydropyrimidine Dehydrogenase (DPYD) Gene in Patients Treated with Fluoropyrimidine-Based Chemotherapy
por: Patel, Girijesh Kumar, et al.
Publicado: (2018)

Vitamin B12 deficiency presenting as pseudo-thrombotic microangiopathy: a case report and literature review
por: Fahmawi, Yazan, et al.
Publicado: (2019)

Detection of mitochondrial DNA mutations in circulating mitochondria-originated extracellular vesicles for potential diagnostic applications in pancreatic adenocarcinoma
por: Vikramdeo, Kunwar Somesh, et al.
Publicado: (2022)

Honokiol Arrests Cell Cycle, Induces Apoptosis, and Potentiates the Cytotoxic Effect of Gemcitabine in Human Pancreatic Cancer Cells
por: Arora, Sumit, et al.
Publicado: (2011)

Synthesis, characterization, and evaluation of poly (D,L-lactide-co-glycolide)-based nanoformulation of miRNA-150: potential implications for pancreatic cancer therapy
por: Arora, Sumit, et al.
Publicado: (2014)

MicroRNA-345 induces apoptosis in pancreatic cancer cells through potentiation of caspase-dependent and -independent pathways
por: Srivastava, Sanjeev K, et al.
Publicado: (2015)

p-21 activated kinase 4 (PAK4) maintains stem cell-like phenotypes in pancreatic cancer cells through activation of STAT3 signaling
por: Tyagi, Nikhil, et al.
Publicado: (2015)

Clinicopathologic significance and race-specific prognostic association of MYB overexpression in ovarian cancer
por: Miree, Orlandric, et al.
Publicado: (2021)

The prevalence and clinical relevance of 2R/2R TYMS genotype in patients with gastrointestinal malignancies treated with fluoropyrimidine-based chemotherapy regimens
por: Khushman, Moh’d, et al.
Publicado: (2021)

p-21 activated kinase 4 promotes proliferation and survival of pancreatic cancer cells through AKT- and ERK-dependent activation of NF-κB pathway
por: Tyagi, Nikhil, et al.
Publicado: (2014)

Development and Characterization of a Novel in vitro Progression Model for UVB-Induced Skin Carcinogenesis
por: Tyagi, Nikhil, et al.
Publicado: (2015)

CXCL12/CXCR4 signaling counteracts docetaxel-induced microtubule stabilization via p21-activated kinase 4-dependent activation of LIM domain kinase 1
por: Bhardwaj, Arun, et al.
Publicado: (2014)

Racial health disparities in ovarian cancer: not just black and white
por: Srivastava, Sanjeev K., et al.
Publicado: (2017)

In silico analyses of isoniazid and streptomycin resistance-associated mutations in Mycobacterium tuberculosis
por: Dasoondi, Rushikesh Singh, et al.
Publicado: (2023)

Resistin and interleukin-6 exhibit racially-disparate expression in breast cancer patients, display molecular association and promote growth and aggressiveness of tumor cells through STAT3 activation
por: Deshmukh, Sachin K., et al.
Publicado: (2015)

In silico-prediction of downstream MYB interacting partners of MAPK3 in Arabidopsis
por: Giri, Priyanka, et al.
Publicado: (2014)

Gemcitabine treatment promotes immunosuppressive microenvironment in pancreatic tumors by supporting the infiltration, growth, and polarization of macrophages
por: Deshmukh, Sachin Kumar, et al.
Publicado: (2018)

Modulation of MicroRNAs by Phytochemicals in Cancer: Underlying Mechanisms and Translational Significance
por: Srivastava, Sanjeev K., et al.
Publicado: (2015)

Therapies Targeted to Androgen Receptor Signaling Axis in Prostate Cancer: Progress, Challenges, and Hope
por: Saranyutanon, Sirin, et al.
Publicado: (2019)

Aloe vera Induced Biomimetic Assemblage of Nucleobase into Nanosized Particles
por: Chauhan, Arun, et al.
Publicado: (2012)

FEM Analysis of Sezawa Mode SAW Sensor for VOC Based on CMOS Compatible AlN/SiO(2)/Si Multilayer Structure
por: Aslam, Muhammad Zubair, et al.
Publicado: (2018)

Design of adaptive ensemble classifier for online sentiment analysis and opinion mining
por: Kumar, Sanjeev, et al.
Publicado: (2021)

ETV4: an emerging target in pancreatic cancer
por: Deshmukh, Sachin Kumar, et al.
Publicado: (2018)

The impact of neoadjuvant concurrent chemoradiation on exosomal markers (CD63 and CD9) expression and their prognostic significance in patients with rectal adenocarcinoma
por: Khushman, Moh’d, et al.
Publicado: (2021)

A new Multi Sine-Cosine algorithm for unconstrained optimization problems
por: Rehman, Muhammad Zubair, et al.
Publicado: (2021)

Analysis of flavonol regulator evolution in the Brassicaceae reveals MYB12, MYB111 and MYB21 duplications and MYB11 and MYB24 gene loss
por: Schilbert, Hanna M., et al.
Publicado: (2022)

The role of MYB34, MYB51 and MYB122 in the regulation of camalexin biosynthesis in Arabidopsis thaliana
por: Frerigmann, Henning, et al.
Publicado: (2015)

In Silico and In Vitro Analyses to Repurpose Quercetin as a Human Pancreatic α-Amylase Inhibitor
por: Raut, Bimal K., et al.
Publicado: (2023)

Structural basis of development of multi-epitope vaccine against Middle East respiratory syndrome using in silico approach
por: Srivastava, Sukrit, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_67f98cvsvbb90enq9hd5590hs6