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Cembranoids from a Chinese Collection of the Soft Coral Lobophytum crassum

Ten new cembrane-based diterpenes, locrassumins A–G (1–7), (–)-laevigatol B (8), (–)-isosarcophine (9), and (–)-7R,8S-dihydroxydeepoxysarcophytoxide (10), were isolated from a South China Sea collection of the soft coral Lobophytum crassum, together with eight known analogues (11–18). The structures...

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Detalles Bibliográficos
Autores principales: Zhao, Min, Cheng, Shimiao, Yuan, Weiping, Xi, Yiyuan, Li, Xiubao, Dong, Jianyong, Huang, Kexin, Gustafson, Kirk R., Yan, Pengcheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926070/
https://www.ncbi.nlm.nih.gov/pubmed/27271640
http://dx.doi.org/10.3390/md14060111
Descripción
Sumario:Ten new cembrane-based diterpenes, locrassumins A–G (1–7), (–)-laevigatol B (8), (–)-isosarcophine (9), and (–)-7R,8S-dihydroxydeepoxysarcophytoxide (10), were isolated from a South China Sea collection of the soft coral Lobophytum crassum, together with eight known analogues (11–18). The structures of the new compounds were determined by extensive spectroscopic analysis and by comparison with previously reported data. Locrassumin C (3) possesses an unprecedented tetradecahydrobenzo[3,4]cyclobuta[1,2][8]annulene ring system. Compounds 1, 7, 12, 13, and 17 exhibited moderate inhibition against lipopolysaccharide (LPS)-induced nitric oxide (NO) production with IC(50) values of 8–24 μM.