Phallusiasterol C, A New Disulfated Steroid from the Mediterranean Tunicate Phallusia fumigata

A new sulfated sterol, phallusiasterol C (1), has been isolated from the Mediterranean ascidian Phallusia fumigata and its structure has been determined on the basis of extensive spectroscopic (mainly 2D NMR) analysis. The possible role in regulating the pregnane X receptor (PXR) activity of phallus...

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Autores principales: Imperatore, Concetta, Senese, Maria, Aiello, Anna, Luciano, Paolo, Fiorucci, Stefano, D’Amore, Claudio, Carino, Adriana, Menna, Marialuisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926076/
https://www.ncbi.nlm.nih.gov/pubmed/27322293
http://dx.doi.org/10.3390/md14060117
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author Imperatore, Concetta
Senese, Maria
Aiello, Anna
Luciano, Paolo
Fiorucci, Stefano
D’Amore, Claudio
Carino, Adriana
Menna, Marialuisa
author_facet Imperatore, Concetta
Senese, Maria
Aiello, Anna
Luciano, Paolo
Fiorucci, Stefano
D’Amore, Claudio
Carino, Adriana
Menna, Marialuisa
author_sort Imperatore, Concetta
collection PubMed
description A new sulfated sterol, phallusiasterol C (1), has been isolated from the Mediterranean ascidian Phallusia fumigata and its structure has been determined on the basis of extensive spectroscopic (mainly 2D NMR) analysis. The possible role in regulating the pregnane X receptor (PXR) activity of phallusiasterol C has been investigated; although the new sterol resulted inactive, this study adds more items to the knowledge of the structure-PXR regulating activity relationships in the case of sulfated steroids.
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spelling pubmed-49260762016-07-06 Phallusiasterol C, A New Disulfated Steroid from the Mediterranean Tunicate Phallusia fumigata Imperatore, Concetta Senese, Maria Aiello, Anna Luciano, Paolo Fiorucci, Stefano D’Amore, Claudio Carino, Adriana Menna, Marialuisa Mar Drugs Article A new sulfated sterol, phallusiasterol C (1), has been isolated from the Mediterranean ascidian Phallusia fumigata and its structure has been determined on the basis of extensive spectroscopic (mainly 2D NMR) analysis. The possible role in regulating the pregnane X receptor (PXR) activity of phallusiasterol C has been investigated; although the new sterol resulted inactive, this study adds more items to the knowledge of the structure-PXR regulating activity relationships in the case of sulfated steroids. MDPI 2016-06-18 /pmc/articles/PMC4926076/ /pubmed/27322293 http://dx.doi.org/10.3390/md14060117 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Imperatore, Concetta
Senese, Maria
Aiello, Anna
Luciano, Paolo
Fiorucci, Stefano
D’Amore, Claudio
Carino, Adriana
Menna, Marialuisa
Phallusiasterol C, A New Disulfated Steroid from the Mediterranean Tunicate Phallusia fumigata
title Phallusiasterol C, A New Disulfated Steroid from the Mediterranean Tunicate Phallusia fumigata
title_full Phallusiasterol C, A New Disulfated Steroid from the Mediterranean Tunicate Phallusia fumigata
title_fullStr Phallusiasterol C, A New Disulfated Steroid from the Mediterranean Tunicate Phallusia fumigata
title_full_unstemmed Phallusiasterol C, A New Disulfated Steroid from the Mediterranean Tunicate Phallusia fumigata
title_short Phallusiasterol C, A New Disulfated Steroid from the Mediterranean Tunicate Phallusia fumigata
title_sort phallusiasterol c, a new disulfated steroid from the mediterranean tunicate phallusia fumigata
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926076/
https://www.ncbi.nlm.nih.gov/pubmed/27322293
http://dx.doi.org/10.3390/md14060117
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