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MRA_1571 is required for isoleucine biosynthesis and improves Mycobacterium tuberculosis H37Ra survival under stress
Threonine dehydratase is a pyridoxal 5-phosphate dependent enzyme required for isoleucine biosynthesis. Threonine dehydratase (IlvA) participates in conversion of threonine to 2-oxobutanoate and ammonia is released as a by-product. MRA_1571 is annotated to be coding for IlvA in Mycobacterium tubercu...
Autores principales: | Sharma, Rishabh, Keshari, Deepa, Singh, Kumar Sachin, Yadav, Shailendra, Singh, Sudheer Kumar |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926081/ https://www.ncbi.nlm.nih.gov/pubmed/27353854 http://dx.doi.org/10.1038/srep27997 |
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