Relationship between vacA Types and Development of Gastroduodenal Diseases

The Helicobacter pylori vacuolating cytotoxin (VacA) is a secreted pore-forming toxin and a major virulence factor in the pathogenesis of H. pylori infection. While VacA is present in almost all strains, only some forms are toxigenic and pathogenic. While vacA and its genotypes are considered as mar...

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Autores principales: Thi Huyen Trang, Tran, Thanh Binh, Tran, Yamaoka, Yoshio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926148/
https://www.ncbi.nlm.nih.gov/pubmed/27294955
http://dx.doi.org/10.3390/toxins8060182
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author Thi Huyen Trang, Tran
Thanh Binh, Tran
Yamaoka, Yoshio
author_facet Thi Huyen Trang, Tran
Thanh Binh, Tran
Yamaoka, Yoshio
author_sort Thi Huyen Trang, Tran
collection PubMed
description The Helicobacter pylori vacuolating cytotoxin (VacA) is a secreted pore-forming toxin and a major virulence factor in the pathogenesis of H. pylori infection. While VacA is present in almost all strains, only some forms are toxigenic and pathogenic. While vacA and its genotypes are considered as markers of H. pylori-related diseases or disorders, the pathophysiological mechanisms of VacA and its genotypes remain controversial. This review outlines key findings of publications regarding vacA with emphasis on the relationship between vacA genotypes and the development of human disease.
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spelling pubmed-49261482016-07-06 Relationship between vacA Types and Development of Gastroduodenal Diseases Thi Huyen Trang, Tran Thanh Binh, Tran Yamaoka, Yoshio Toxins (Basel) Review The Helicobacter pylori vacuolating cytotoxin (VacA) is a secreted pore-forming toxin and a major virulence factor in the pathogenesis of H. pylori infection. While VacA is present in almost all strains, only some forms are toxigenic and pathogenic. While vacA and its genotypes are considered as markers of H. pylori-related diseases or disorders, the pathophysiological mechanisms of VacA and its genotypes remain controversial. This review outlines key findings of publications regarding vacA with emphasis on the relationship between vacA genotypes and the development of human disease. MDPI 2016-06-09 /pmc/articles/PMC4926148/ /pubmed/27294955 http://dx.doi.org/10.3390/toxins8060182 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Thi Huyen Trang, Tran
Thanh Binh, Tran
Yamaoka, Yoshio
Relationship between vacA Types and Development of Gastroduodenal Diseases
title Relationship between vacA Types and Development of Gastroduodenal Diseases
title_full Relationship between vacA Types and Development of Gastroduodenal Diseases
title_fullStr Relationship between vacA Types and Development of Gastroduodenal Diseases
title_full_unstemmed Relationship between vacA Types and Development of Gastroduodenal Diseases
title_short Relationship between vacA Types and Development of Gastroduodenal Diseases
title_sort relationship between vaca types and development of gastroduodenal diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926148/
https://www.ncbi.nlm.nih.gov/pubmed/27294955
http://dx.doi.org/10.3390/toxins8060182
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