Marburg Virus Reverse Genetics Systems

The highly pathogenic Marburg virus (MARV) is a member of the Filoviridae family and belongs to the group of nonsegmented negative-strand RNA viruses. Reverse genetics systems established for MARV have been used to study various aspects of the viral replication cycle, analyze host responses, image v...

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Detalles Bibliográficos
Autores principales: Schmidt, Kristina Maria, Mühlberger, Elke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926198/
https://www.ncbi.nlm.nih.gov/pubmed/27338448
http://dx.doi.org/10.3390/v8060178
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author Schmidt, Kristina Maria
Mühlberger, Elke
author_facet Schmidt, Kristina Maria
Mühlberger, Elke
author_sort Schmidt, Kristina Maria
collection PubMed
description The highly pathogenic Marburg virus (MARV) is a member of the Filoviridae family and belongs to the group of nonsegmented negative-strand RNA viruses. Reverse genetics systems established for MARV have been used to study various aspects of the viral replication cycle, analyze host responses, image viral infection, and screen for antivirals. This article provides an overview of the currently established MARV reverse genetic systems based on minigenomes, infectious virus-like particles and full-length clones, and the research that has been conducted using these systems.
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spelling pubmed-49261982016-07-06 Marburg Virus Reverse Genetics Systems Schmidt, Kristina Maria Mühlberger, Elke Viruses Review The highly pathogenic Marburg virus (MARV) is a member of the Filoviridae family and belongs to the group of nonsegmented negative-strand RNA viruses. Reverse genetics systems established for MARV have been used to study various aspects of the viral replication cycle, analyze host responses, image viral infection, and screen for antivirals. This article provides an overview of the currently established MARV reverse genetic systems based on minigenomes, infectious virus-like particles and full-length clones, and the research that has been conducted using these systems. MDPI 2016-06-22 /pmc/articles/PMC4926198/ /pubmed/27338448 http://dx.doi.org/10.3390/v8060178 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Schmidt, Kristina Maria
Mühlberger, Elke
Marburg Virus Reverse Genetics Systems
title Marburg Virus Reverse Genetics Systems
title_full Marburg Virus Reverse Genetics Systems
title_fullStr Marburg Virus Reverse Genetics Systems
title_full_unstemmed Marburg Virus Reverse Genetics Systems
title_short Marburg Virus Reverse Genetics Systems
title_sort marburg virus reverse genetics systems
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926198/
https://www.ncbi.nlm.nih.gov/pubmed/27338448
http://dx.doi.org/10.3390/v8060178
work_keys_str_mv AT schmidtkristinamaria marburgvirusreversegeneticssystems
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