Autism phenotypes in ZnT3 null mice: Involvement of zinc dyshomeostasis, MMP-9 activation and BDNF upregulation

To investigate the role of synaptic zinc in the ASD pathogenesis, we examined zinc transporter 3 (ZnT3) null mice. At 4–5 weeks of age, male but not female ZnT3 null mice exhibited autistic-like behaviors. Cortical volume and neurite density were significantly greater in male ZnT3 null mice than in...

Descripción completa

Detalles Bibliográficos
Autores principales: Yoo, Min Heui, Kim, Tae-Youn, Yoon, Young Hee, Koh, Jae-Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926223/
https://www.ncbi.nlm.nih.gov/pubmed/27352957
http://dx.doi.org/10.1038/srep28548

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926223/
https://www.ncbi.nlm.nih.gov/pubmed/27352957
http://dx.doi.org/10.1038/srep28548

Ejemplares similares