Efficient production of multi-modified pigs for xenotransplantation by ‘combineering’, gene stacking and gene editing

Xenotransplantation from pigs could alleviate the shortage of human tissues and organs for transplantation. Means have been identified to overcome hyperacute rejection and acute vascular rejection mechanisms mounted by the recipient. The challenge is to combine multiple genetic modifications to enab...

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Detalles Bibliográficos
Autores principales: Fischer, Konrad, Kraner-Scheiber, Simone, Petersen, Björn, Rieblinger, Beate, Buermann, Anna, Flisikowska, Tatiana, Flisikowski, Krzysztof, Christan, Susanne, Edlinger, Marlene, Baars, Wiebke, Kurome, Mayuko, Zakhartchenko, Valeri, Kessler, Barbara, Plotzki, Elena, Szczerbal, Izabela, Switonski, Marek, Denner, Joachim, Wolf, Eckhard, Schwinzer, Reinhard, Niemann, Heiner, Kind, Alexander, Schnieke, Angelika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926246/
https://www.ncbi.nlm.nih.gov/pubmed/27353424
http://dx.doi.org/10.1038/srep29081

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