Surrogate endpoints and competing risk of death in cardiac arrest research

We urgently need new therapies to improve outcomes after cardiac arrest. Initial studies typically target surrogate endpoints, and these studies help to inform subsequent larger trials that are powered to measure more patient-orientated clinical outcomes such as survival. The competing risk of death...

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Detalles Bibliográficos
Autores principales: McCredie, Victoria A., Scales, Damon C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926290/
https://www.ncbi.nlm.nih.gov/pubmed/27353499
http://dx.doi.org/10.1186/s13054-016-1345-y
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author McCredie, Victoria A.
Scales, Damon C.
author_facet McCredie, Victoria A.
Scales, Damon C.
author_sort McCredie, Victoria A.
collection PubMed
description We urgently need new therapies to improve outcomes after cardiac arrest. Initial studies typically target surrogate endpoints, and these studies help to inform subsequent larger trials that are powered to measure more patient-orientated clinical outcomes such as survival. The competing risk of death and premature assessment of neurological prognosis pose significant challenges to measuring these surrogate endpoints after cardiac arrest.
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spelling pubmed-49262902016-06-29 Surrogate endpoints and competing risk of death in cardiac arrest research McCredie, Victoria A. Scales, Damon C. Crit Care Commentary We urgently need new therapies to improve outcomes after cardiac arrest. Initial studies typically target surrogate endpoints, and these studies help to inform subsequent larger trials that are powered to measure more patient-orientated clinical outcomes such as survival. The competing risk of death and premature assessment of neurological prognosis pose significant challenges to measuring these surrogate endpoints after cardiac arrest. BioMed Central 2016-06-29 2016 /pmc/articles/PMC4926290/ /pubmed/27353499 http://dx.doi.org/10.1186/s13054-016-1345-y Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Commentary
McCredie, Victoria A.
Scales, Damon C.
Surrogate endpoints and competing risk of death in cardiac arrest research
title Surrogate endpoints and competing risk of death in cardiac arrest research
title_full Surrogate endpoints and competing risk of death in cardiac arrest research
title_fullStr Surrogate endpoints and competing risk of death in cardiac arrest research
title_full_unstemmed Surrogate endpoints and competing risk of death in cardiac arrest research
title_short Surrogate endpoints and competing risk of death in cardiac arrest research
title_sort surrogate endpoints and competing risk of death in cardiac arrest research
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926290/
https://www.ncbi.nlm.nih.gov/pubmed/27353499
http://dx.doi.org/10.1186/s13054-016-1345-y
work_keys_str_mv AT mccredievictoriaa surrogateendpointsandcompetingriskofdeathincardiacarrestresearch
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