The Leishmaniasis East Africa Platform (LEAP): strengthening clinical trial capacity in resource-limited countries to deliver new treatments for visceral leishmaniasis

Visceral leishmaniasis is a neglected tropical disease endemic in East Africa where improved patient-adapted treatments are needed. The Leishmaniasis East Africa Platform (LEAP) was created in 2003 to strengthen clinical research capacity, serve as a base for training, and evaluate and facilitate im...

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Autores principales: Wasunna, Monique, Musa, Ahmed, Hailu, Asrat, Khalil, Eltahir A. G., Olobo, Joseph, Juma, Rashid, Wells, Susan, Alvar, Jorge, Balasegaram, Manica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926319/
https://www.ncbi.nlm.nih.gov/pubmed/27268714
http://dx.doi.org/10.1093/trstmh/trw031
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author Wasunna, Monique
Musa, Ahmed
Hailu, Asrat
Khalil, Eltahir A. G.
Olobo, Joseph
Juma, Rashid
Wells, Susan
Alvar, Jorge
Balasegaram, Manica
author_facet Wasunna, Monique
Musa, Ahmed
Hailu, Asrat
Khalil, Eltahir A. G.
Olobo, Joseph
Juma, Rashid
Wells, Susan
Alvar, Jorge
Balasegaram, Manica
author_sort Wasunna, Monique
collection PubMed
description Visceral leishmaniasis is a neglected tropical disease endemic in East Africa where improved patient-adapted treatments are needed. The Leishmaniasis East Africa Platform (LEAP) was created in 2003 to strengthen clinical research capacity, serve as a base for training, and evaluate and facilitate implementation of new treatments. Major infrastructure upgrades and personnel training have been carried out. A short course of Sodium Stibogluconate and Paramomycin (SSG&PM) was evaluated and is now first-line treatment in the region; alternative treatments have also been assessed. LEAP can serve as a successful model of collaboration between different partners and countries when conducting clinical research in endemic countries to international standards.
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spelling pubmed-49263192016-07-05 The Leishmaniasis East Africa Platform (LEAP): strengthening clinical trial capacity in resource-limited countries to deliver new treatments for visceral leishmaniasis Wasunna, Monique Musa, Ahmed Hailu, Asrat Khalil, Eltahir A. G. Olobo, Joseph Juma, Rashid Wells, Susan Alvar, Jorge Balasegaram, Manica Trans R Soc Trop Med Hyg Commentary Visceral leishmaniasis is a neglected tropical disease endemic in East Africa where improved patient-adapted treatments are needed. The Leishmaniasis East Africa Platform (LEAP) was created in 2003 to strengthen clinical research capacity, serve as a base for training, and evaluate and facilitate implementation of new treatments. Major infrastructure upgrades and personnel training have been carried out. A short course of Sodium Stibogluconate and Paramomycin (SSG&PM) was evaluated and is now first-line treatment in the region; alternative treatments have also been assessed. LEAP can serve as a successful model of collaboration between different partners and countries when conducting clinical research in endemic countries to international standards. Oxford University Press 2016-06 2016-06-28 /pmc/articles/PMC4926319/ /pubmed/27268714 http://dx.doi.org/10.1093/trstmh/trw031 Text en © The Author 2016. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Commentary
Wasunna, Monique
Musa, Ahmed
Hailu, Asrat
Khalil, Eltahir A. G.
Olobo, Joseph
Juma, Rashid
Wells, Susan
Alvar, Jorge
Balasegaram, Manica
The Leishmaniasis East Africa Platform (LEAP): strengthening clinical trial capacity in resource-limited countries to deliver new treatments for visceral leishmaniasis
title The Leishmaniasis East Africa Platform (LEAP): strengthening clinical trial capacity in resource-limited countries to deliver new treatments for visceral leishmaniasis
title_full The Leishmaniasis East Africa Platform (LEAP): strengthening clinical trial capacity in resource-limited countries to deliver new treatments for visceral leishmaniasis
title_fullStr The Leishmaniasis East Africa Platform (LEAP): strengthening clinical trial capacity in resource-limited countries to deliver new treatments for visceral leishmaniasis
title_full_unstemmed The Leishmaniasis East Africa Platform (LEAP): strengthening clinical trial capacity in resource-limited countries to deliver new treatments for visceral leishmaniasis
title_short The Leishmaniasis East Africa Platform (LEAP): strengthening clinical trial capacity in resource-limited countries to deliver new treatments for visceral leishmaniasis
title_sort leishmaniasis east africa platform (leap): strengthening clinical trial capacity in resource-limited countries to deliver new treatments for visceral leishmaniasis
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926319/
https://www.ncbi.nlm.nih.gov/pubmed/27268714
http://dx.doi.org/10.1093/trstmh/trw031
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