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MicroRNA-31 Emerges as a Predictive Biomarker of Pathological Response and Outcome in Locally Advanced Rectal Cancer
Neoadjuvant chemoradiotherapy (CRT) followed by total mesorectal excision has emerged as the standard treatment for locally advanced rectal cancer (LARC) patients. However, many cases do not respond to neoadjuvant CRT, suffering unnecessary toxicities and surgery delays. Thus, identification of pred...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926412/ https://www.ncbi.nlm.nih.gov/pubmed/27271609 http://dx.doi.org/10.3390/ijms17060878 |
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author | Caramés, Cristina Cristobal, Ion Moreno, Víctor Marín, Juan P. González-Alonso, Paula Torrejón, Blanca Minguez, Pablo Leon, Ana Martín, José I. Hernández, Roberto Pedregal, Manuel Martín, María J. Cortés, Delia García-Olmo, Damian Fernández, María J. Rojo, Federico García-Foncillas, Jesús |
author_facet | Caramés, Cristina Cristobal, Ion Moreno, Víctor Marín, Juan P. González-Alonso, Paula Torrejón, Blanca Minguez, Pablo Leon, Ana Martín, José I. Hernández, Roberto Pedregal, Manuel Martín, María J. Cortés, Delia García-Olmo, Damian Fernández, María J. Rojo, Federico García-Foncillas, Jesús |
author_sort | Caramés, Cristina |
collection | PubMed |
description | Neoadjuvant chemoradiotherapy (CRT) followed by total mesorectal excision has emerged as the standard treatment for locally advanced rectal cancer (LARC) patients. However, many cases do not respond to neoadjuvant CRT, suffering unnecessary toxicities and surgery delays. Thus, identification of predictive biomarkers for neoadjuvant CRT is a current clinical need. In the present study, microRNA-31 expression was measured in formalin-fixed paraffin-embedded (FFPE) biopsies from 78 patients diagnosed with LARC who were treated with neoadjuvant CRT. Then, the obtained results were correlated with clinical and pathological characteristics and outcome. High microRNA-31 (miR-31) levels were found overexpressed in 34.2% of cases. Its overexpression significantly predicted poor pathological response (p = 0.018) and worse overall survival (OS) (p = 0.008). The odds ratio for no pathological response among patients with miR-31 overexpression was 0.18 (Confidence Interval = 0.06 to 0.57; p = 0.003). Multivariate analysis corroborated the clinical impact of miR-31 in determining pathological response to neoadjuvant CRT as well as OS. Altogether, miR-31 quantification emerges as a novel valuable clinical tool to predict both pathological response and outcome in LARC patients. |
format | Online Article Text |
id | pubmed-4926412 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-49264122016-07-06 MicroRNA-31 Emerges as a Predictive Biomarker of Pathological Response and Outcome in Locally Advanced Rectal Cancer Caramés, Cristina Cristobal, Ion Moreno, Víctor Marín, Juan P. González-Alonso, Paula Torrejón, Blanca Minguez, Pablo Leon, Ana Martín, José I. Hernández, Roberto Pedregal, Manuel Martín, María J. Cortés, Delia García-Olmo, Damian Fernández, María J. Rojo, Federico García-Foncillas, Jesús Int J Mol Sci Article Neoadjuvant chemoradiotherapy (CRT) followed by total mesorectal excision has emerged as the standard treatment for locally advanced rectal cancer (LARC) patients. However, many cases do not respond to neoadjuvant CRT, suffering unnecessary toxicities and surgery delays. Thus, identification of predictive biomarkers for neoadjuvant CRT is a current clinical need. In the present study, microRNA-31 expression was measured in formalin-fixed paraffin-embedded (FFPE) biopsies from 78 patients diagnosed with LARC who were treated with neoadjuvant CRT. Then, the obtained results were correlated with clinical and pathological characteristics and outcome. High microRNA-31 (miR-31) levels were found overexpressed in 34.2% of cases. Its overexpression significantly predicted poor pathological response (p = 0.018) and worse overall survival (OS) (p = 0.008). The odds ratio for no pathological response among patients with miR-31 overexpression was 0.18 (Confidence Interval = 0.06 to 0.57; p = 0.003). Multivariate analysis corroborated the clinical impact of miR-31 in determining pathological response to neoadjuvant CRT as well as OS. Altogether, miR-31 quantification emerges as a novel valuable clinical tool to predict both pathological response and outcome in LARC patients. MDPI 2016-06-03 /pmc/articles/PMC4926412/ /pubmed/27271609 http://dx.doi.org/10.3390/ijms17060878 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Caramés, Cristina Cristobal, Ion Moreno, Víctor Marín, Juan P. González-Alonso, Paula Torrejón, Blanca Minguez, Pablo Leon, Ana Martín, José I. Hernández, Roberto Pedregal, Manuel Martín, María J. Cortés, Delia García-Olmo, Damian Fernández, María J. Rojo, Federico García-Foncillas, Jesús MicroRNA-31 Emerges as a Predictive Biomarker of Pathological Response and Outcome in Locally Advanced Rectal Cancer |
title | MicroRNA-31 Emerges as a Predictive Biomarker of Pathological Response and Outcome in Locally Advanced Rectal Cancer |
title_full | MicroRNA-31 Emerges as a Predictive Biomarker of Pathological Response and Outcome in Locally Advanced Rectal Cancer |
title_fullStr | MicroRNA-31 Emerges as a Predictive Biomarker of Pathological Response and Outcome in Locally Advanced Rectal Cancer |
title_full_unstemmed | MicroRNA-31 Emerges as a Predictive Biomarker of Pathological Response and Outcome in Locally Advanced Rectal Cancer |
title_short | MicroRNA-31 Emerges as a Predictive Biomarker of Pathological Response and Outcome in Locally Advanced Rectal Cancer |
title_sort | microrna-31 emerges as a predictive biomarker of pathological response and outcome in locally advanced rectal cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926412/ https://www.ncbi.nlm.nih.gov/pubmed/27271609 http://dx.doi.org/10.3390/ijms17060878 |
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