Cargando…

Tetrapyrroles as Endogenous TSPO Ligands in Eukaryotes and Prokaryotes: Comparisons with Synthetic Ligands

The 18 kDa translocator protein (TSPO) is highly 0conserved in eukaryotes and prokaryotes. Since its discovery in 1977, numerous studies established the TSPO’s importance for life essential functions. For these studies, synthetic TSPO ligands typically are applied. Tetrapyrroles present endogenous l...

Descripción completa

Detalles Bibliográficos
Autores principales:	Veenman, Leo, Vainshtein, Alex, Yasin, Nasra, Azrad, Maya, Gavish, Moshe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2016
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926414/ https://www.ncbi.nlm.nih.gov/pubmed/27271616 http://dx.doi.org/10.3390/ijms17060880

Ejemplares similares

Classical and Novel TSPO Ligands for the Mitochondrial TSPO Can Modulate Nuclear Gene Expression: Implications for Mitochondrial Retrograde Signaling
por: Yasin, Nasra, et al.
Publicado: (2017)

The TSPO Ligands 2-Cl-MGV-1, MGV-1, and PK11195 Differentially Suppress the Inflammatory Response of BV-2 Microglial Cell to LPS
por: Azrad, Maya, et al.
Publicado: (2019)

TSPO as a target for treatments of diseases, including neuropathological disorders
por: Veenman, L, et al.
Publicado: (2015)

The Efficacy of the Novel TSPO Ligands 2-Cl-MGV-1 and 2,4-Di-Cl-MGV-1 Compared to the Classical TSPO Ligand PK 11195 to Counteract the Release of Chemokines from LPS-Stimulated BV-2 Microglial Cells
por: Monga, Sheelu, et al.
Publicado: (2020)

Binding Affinity of Some Endogenous and Synthetic TSPO Ligands Regarding the rs6971 Polymorphism
por: Berroterán-Infante, Neydher, et al.
Publicado: (2019)

Inhibitory Effects of the Two Novel TSPO Ligands 2-Cl-MGV-1 and MGV-1 on LPS-induced Microglial Activation
por: Monga, Sheelu, et al.
Publicado: (2019)

Ligands of the Mitochondrial 18 kDa Translocator Protein Attenuate Apoptosis of Human Glioblastoma Cells Exposed to Erucylphosphohomocholine
por: Kugler, Wilfried, et al.
Publicado: (2008)

The Effect of the Classical TSPO Ligand PK 11195 on In Vitro Cobalt Chloride Model of Hypoxia-like Condition in Lung and Brain Cell Lines
por: Amara, Rula, et al.
Publicado: (2022)

The Neuro-Protective Effects of the TSPO Ligands CB86 and CB204 on 6-OHDA-Induced PC12 Cell Death as an In Vitro Model for Parkinson’s Disease
por: Monga, Sheelu, et al.
Publicado: (2021)

The TSPO Ligands MGV-1 and 2-Cl-MGV-1 Differentially Inhibit the Cigarette Smoke-Induced Cytotoxicity to H1299 Lung Cancer Cells
por: Zeineh, Nidal, et al.
Publicado: (2021)

Efficaciousness of Low Affinity Compared to High Affinity TSPO Ligands in the Inhibition of Hypoxic Mitochondrial Cellular Damage Induced by Cobalt Chloride in Human Lung H1299 Cells
por: Zeineh, Nidal, et al.
Publicado: (2020)

Effects of Cigarette Smoke on TSPO-related Mitochondrial Processes
por: Zeineh, Nidal, et al.
Publicado: (2019)

Reduction of Traumatic Brain Damage by Tspo Ligand Etifoxine
por: Shehadeh, Mona, et al.
Publicado: (2019)

TSPO Ligands Boost Mitochondrial Function and Pregnenolone Synthesis
por: Lejri, Imane, et al.
Publicado: (2019)

The Arabidopsis translocator protein (AtTSPO) is regulated at multiple levels in response to salt stress and perturbations in tetrapyrrole metabolism
por: Balsemão-Pires, Emilia, et al.
Publicado: (2011)

Reprogramming Eukaryotic Translation with Ligand-Responsive Synthetic RNA Switches
por: Anzalone, Andrew V., et al.
Publicado: (2016)

The protective effect of the TSPO ligands 2,4-Di-Cl-MGV-1, CB86, and CB204 against LPS-induced M1 pro-inflammatory activation of microglia
por: Monga, Sheelu, et al.
Publicado: (2020)

Prokaryotic nanocompartments form synthetic organelles in a eukaryote
por: Lau, Yu Heng, et al.
Publicado: (2018)

Reactive Cobalt–Oxo Complexes of Tetrapyrrolic Macrocycles and N-based Ligand in Oxidative Transformation Reactions
por: Ali, Atif, et al.
Publicado: (2018)

Molecular Engineering of Free‐Base Porphyrins as Ligands—The N−H⋅⋅⋅X Binding Motif in Tetrapyrroles
por: Kielmann, Marc, et al.
Publicado: (2018)

A TSPO ligand is protective in a mouse model of multiple sclerosis
por: Daugherty, Daniel J, et al.
Publicado: (2013)

TSPO PIGA Ligands Promote Neurosteroidogenesis and Human Astrocyte Well-Being
por: Da Pozzo, Eleonora, et al.
Publicado: (2016)

TSPO Ligand-Methotrexate Prodrug Conjugates: Design, Synthesis, and Biological Evaluation
por: Laquintana, Valentino, et al.
Publicado: (2016)

Determination and reduction of translocator protein (TSPO) ligand rs6971 discrimination
por: Sokias, Renee, et al.
Publicado: (2016)

A TSPO ligand attenuates brain injury after intracerebral hemorrhage
por: Li, Minshu, et al.
Publicado: (2017)

Macroscopic Kinetics of Pentameric Ligand Gated Ion Channels: Comparisons between Two Prokaryotic Channels and One Eukaryotic Channel
por: Laha, Kurt T., et al.
Publicado: (2013)

Ligand Activation of the Prokaryotic Pentameric Ligand-Gated Ion Channel ELIC
por: Zimmermann, Iwan, et al.
Publicado: (2011)

Diagnostic and Therapeutic Potential of TSPO Studies Regarding Neurodegenerative Diseases, Psychiatric Disorders, Alcohol Use Disorders, Traumatic Brain Injury, and Stroke: An Update
por: Dimitrova-Shumkovska, Jasmina, et al.
Publicado: (2020)

Delivery of Proapoptotic Agents in Glioma Cell Lines by TSPO Ligand–Dextran Nanogels
por: Lopalco, Antonio, et al.
Publicado: (2018)

Characterization of the High-Affinity Drug Ligand Binding Site of Mouse Recombinant TSPO
por: Iatmanen-Harbi, Soria, et al.
Publicado: (2019)

Mitochondria modulatory effects of new TSPO ligands in a cellular model of tauopathies
por: Grimm, Amandine, et al.
Publicado: (2019)

The New Dipeptide TSPO Ligands: Design, Synthesis and Structure–Anxiolytic Activity Relationship †
por: Gudasheva, Tatiana A., et al.
Publicado: (2020)

Tetrapyrrole Signaling in Plants
por: Larkin, Robert M.
Publicado: (2016)

TSPO ligand residence time: a new parameter to predict compound neurosteroidogenic efficacy
por: Costa, Barbara, et al.
Publicado: (2016)

Preclinical TSPO Ligand PET to Visualize Human Glioma Xenotransplants: A Preliminary Study
por: Buck, Jason R., et al.
Publicado: (2015)

The Interplay of Cholesterol and Ligand Binding in hTSPO from Classical Molecular Dynamics Simulations
por: Lai, Hien T. T., et al.
Publicado: (2021)

Fully Automated Synthesis of Novel TSPO PET Imaging Ligand [(18)F]Fluoroethyltemazepam
por: Fiorenza, Dario, et al.
Publicado: (2021)

Sigma-2 Receptor Ligand Binding Modulates Association between TSPO and TMEM97
por: Thejer, Bashar M., et al.
Publicado: (2023)

Potent synthetic and endogenous ligands for the adopted orphan nuclear receptor Nurr1
por: Jang, Yongwoo, et al.
Publicado: (2021)

TSPO Ligands Promote Cholesterol Efflux and Suppress Oxidative Stress and Inflammation in Choroidal Endothelial Cells
por: Biswas, Lincoln, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_k80kqfj2jpo8uhifp0riqmr5lq