The Role of miRNA in Papillary Thyroid Cancer in the Context of miRNA Let-7 Family

Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy. RET/PTC rearrangement is the most common genetic modification identified in this category of cancer, increasing proliferation and dedifferentiation by the activation of the RET/PTC-RAS-BRAF-MAPK-ERK signaling pathway. Recentl...

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Detalles Bibliográficos
Autores principales: Perdas, Ewelina, Stawski, Robert, Nowak, Dariusz, Zubrzycka, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926443/
https://www.ncbi.nlm.nih.gov/pubmed/27314338
http://dx.doi.org/10.3390/ijms17060909
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author Perdas, Ewelina
Stawski, Robert
Nowak, Dariusz
Zubrzycka, Maria
author_facet Perdas, Ewelina
Stawski, Robert
Nowak, Dariusz
Zubrzycka, Maria
author_sort Perdas, Ewelina
collection PubMed
description Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy. RET/PTC rearrangement is the most common genetic modification identified in this category of cancer, increasing proliferation and dedifferentiation by the activation of the RET/PTC-RAS-BRAF-MAPK-ERK signaling pathway. Recently, let-7 miRNA was found to reduce RAS levels, acting as a tumor suppressor gene. Circulating miRNA profiles of the let-7 family may be used as novel noninvasive diagnostic, prognostic, treatment and surveillance markers for PTC.
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spelling pubmed-49264432016-07-06 The Role of miRNA in Papillary Thyroid Cancer in the Context of miRNA Let-7 Family Perdas, Ewelina Stawski, Robert Nowak, Dariusz Zubrzycka, Maria Int J Mol Sci Review Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy. RET/PTC rearrangement is the most common genetic modification identified in this category of cancer, increasing proliferation and dedifferentiation by the activation of the RET/PTC-RAS-BRAF-MAPK-ERK signaling pathway. Recently, let-7 miRNA was found to reduce RAS levels, acting as a tumor suppressor gene. Circulating miRNA profiles of the let-7 family may be used as novel noninvasive diagnostic, prognostic, treatment and surveillance markers for PTC. MDPI 2016-06-15 /pmc/articles/PMC4926443/ /pubmed/27314338 http://dx.doi.org/10.3390/ijms17060909 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Perdas, Ewelina
Stawski, Robert
Nowak, Dariusz
Zubrzycka, Maria
The Role of miRNA in Papillary Thyroid Cancer in the Context of miRNA Let-7 Family
title The Role of miRNA in Papillary Thyroid Cancer in the Context of miRNA Let-7 Family
title_full The Role of miRNA in Papillary Thyroid Cancer in the Context of miRNA Let-7 Family
title_fullStr The Role of miRNA in Papillary Thyroid Cancer in the Context of miRNA Let-7 Family
title_full_unstemmed The Role of miRNA in Papillary Thyroid Cancer in the Context of miRNA Let-7 Family
title_short The Role of miRNA in Papillary Thyroid Cancer in the Context of miRNA Let-7 Family
title_sort role of mirna in papillary thyroid cancer in the context of mirna let-7 family
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926443/
https://www.ncbi.nlm.nih.gov/pubmed/27314338
http://dx.doi.org/10.3390/ijms17060909
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