Inhibition of SDF-1α/CXCR4 Signalling in Subchondral Bone Attenuates Post-Traumatic Osteoarthritis

Previous studies showed that SDF-1α is a catabolic factor that can infiltrate cartilage, decrease proteoglycan content, and increase MMP-13 activity. Inhibiting the SDF-1α/CXCR4 signalling pathway can attenuate the pathogenesis of osteoarthritis (OA). Recent studies have also shown that SDF-1α enhan...

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Detalles Bibliográficos
Autores principales: Dong, Yonghui, Liu, Hui, Zhang, Xuejun, Xu, Fei, Qin, Liang, Cheng, Peng, Huang, Hui, Guo, Fengjing, Yang, Qing, Chen, Anmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926476/
https://www.ncbi.nlm.nih.gov/pubmed/27322244
http://dx.doi.org/10.3390/ijms17060943

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