Aquaporins in Urinary Extracellular Vesicles (Exosomes)

Since the successful characterization of urinary extracellular vesicles (uEVs) by Knepper’s group in 2004, these vesicles have been a focus of intense basic and translational research worldwide, with the aim of developing novel biomarkers and therapeutics for renal disease. Along with these studies,...

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Detalles Bibliográficos
Autores principales: Oshikawa, Sayaka, Sonoda, Hiroko, Ikeda, Masahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926490/
https://www.ncbi.nlm.nih.gov/pubmed/27322253
http://dx.doi.org/10.3390/ijms17060957
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author Oshikawa, Sayaka
Sonoda, Hiroko
Ikeda, Masahiro
author_facet Oshikawa, Sayaka
Sonoda, Hiroko
Ikeda, Masahiro
author_sort Oshikawa, Sayaka
collection PubMed
description Since the successful characterization of urinary extracellular vesicles (uEVs) by Knepper’s group in 2004, these vesicles have been a focus of intense basic and translational research worldwide, with the aim of developing novel biomarkers and therapeutics for renal disease. Along with these studies, there is growing evidence that aquaporins (AQPs), water channel proteins, in uEVs have the potential to be diagnostically useful. In this review, we highlight current knowledge of AQPs in uEVs from their discovery to clinical application.
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spelling pubmed-49264902016-07-06 Aquaporins in Urinary Extracellular Vesicles (Exosomes) Oshikawa, Sayaka Sonoda, Hiroko Ikeda, Masahiro Int J Mol Sci Review Since the successful characterization of urinary extracellular vesicles (uEVs) by Knepper’s group in 2004, these vesicles have been a focus of intense basic and translational research worldwide, with the aim of developing novel biomarkers and therapeutics for renal disease. Along with these studies, there is growing evidence that aquaporins (AQPs), water channel proteins, in uEVs have the potential to be diagnostically useful. In this review, we highlight current knowledge of AQPs in uEVs from their discovery to clinical application. MDPI 2016-06-17 /pmc/articles/PMC4926490/ /pubmed/27322253 http://dx.doi.org/10.3390/ijms17060957 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Oshikawa, Sayaka
Sonoda, Hiroko
Ikeda, Masahiro
Aquaporins in Urinary Extracellular Vesicles (Exosomes)
title Aquaporins in Urinary Extracellular Vesicles (Exosomes)
title_full Aquaporins in Urinary Extracellular Vesicles (Exosomes)
title_fullStr Aquaporins in Urinary Extracellular Vesicles (Exosomes)
title_full_unstemmed Aquaporins in Urinary Extracellular Vesicles (Exosomes)
title_short Aquaporins in Urinary Extracellular Vesicles (Exosomes)
title_sort aquaporins in urinary extracellular vesicles (exosomes)
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926490/
https://www.ncbi.nlm.nih.gov/pubmed/27322253
http://dx.doi.org/10.3390/ijms17060957
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