Cargando…
Targeting the Innate Immune Response to Improve Cardiac Graft Recovery after Heart Transplantation: Implications for the Donation after Cardiac Death
Heart transplantation (HTx) is the ultimate treatment for end-stage heart failure. The number of patients on waiting lists for heart transplants, however, is much higher than the number of available organs. The shortage of donor hearts is a serious concern since the population affected by heart fail...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926491/ https://www.ncbi.nlm.nih.gov/pubmed/27322252 http://dx.doi.org/10.3390/ijms17060958 |
_version_ | 1782440125537452032 |
---|---|
author | Toldo, Stefano Quader, Mohammed Salloum, Fadi N. Mezzaroma, Eleonora Abbate, Antonio |
author_facet | Toldo, Stefano Quader, Mohammed Salloum, Fadi N. Mezzaroma, Eleonora Abbate, Antonio |
author_sort | Toldo, Stefano |
collection | PubMed |
description | Heart transplantation (HTx) is the ultimate treatment for end-stage heart failure. The number of patients on waiting lists for heart transplants, however, is much higher than the number of available organs. The shortage of donor hearts is a serious concern since the population affected by heart failure is constantly increasing. Furthermore, the long-term success of HTx poses some challenges despite the improvement in the management of the short-term complications and in the methods to limit graft rejection. Myocardial injury occurs during transplantation. Injury initiated in the donor as result of brain or cardiac death is exacerbated by organ procurement and storage, and is ultimately amplified by reperfusion injury at the time of transplantation. The innate immune system is a mechanism of first-line defense against pathogens and cell injury. Innate immunity is activated during myocardial injury and produces deleterious effects on the heart structure and function. Here, we briefly discuss the role of the innate immunity in the initiation of myocardial injury, with particular focus on the Toll-like receptors and inflammasome, and how to potentially expand the donor population by targeting the innate immune response. |
format | Online Article Text |
id | pubmed-4926491 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-49264912016-07-06 Targeting the Innate Immune Response to Improve Cardiac Graft Recovery after Heart Transplantation: Implications for the Donation after Cardiac Death Toldo, Stefano Quader, Mohammed Salloum, Fadi N. Mezzaroma, Eleonora Abbate, Antonio Int J Mol Sci Review Heart transplantation (HTx) is the ultimate treatment for end-stage heart failure. The number of patients on waiting lists for heart transplants, however, is much higher than the number of available organs. The shortage of donor hearts is a serious concern since the population affected by heart failure is constantly increasing. Furthermore, the long-term success of HTx poses some challenges despite the improvement in the management of the short-term complications and in the methods to limit graft rejection. Myocardial injury occurs during transplantation. Injury initiated in the donor as result of brain or cardiac death is exacerbated by organ procurement and storage, and is ultimately amplified by reperfusion injury at the time of transplantation. The innate immune system is a mechanism of first-line defense against pathogens and cell injury. Innate immunity is activated during myocardial injury and produces deleterious effects on the heart structure and function. Here, we briefly discuss the role of the innate immunity in the initiation of myocardial injury, with particular focus on the Toll-like receptors and inflammasome, and how to potentially expand the donor population by targeting the innate immune response. MDPI 2016-06-17 /pmc/articles/PMC4926491/ /pubmed/27322252 http://dx.doi.org/10.3390/ijms17060958 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Toldo, Stefano Quader, Mohammed Salloum, Fadi N. Mezzaroma, Eleonora Abbate, Antonio Targeting the Innate Immune Response to Improve Cardiac Graft Recovery after Heart Transplantation: Implications for the Donation after Cardiac Death |
title | Targeting the Innate Immune Response to Improve Cardiac Graft Recovery after Heart Transplantation: Implications for the Donation after Cardiac Death |
title_full | Targeting the Innate Immune Response to Improve Cardiac Graft Recovery after Heart Transplantation: Implications for the Donation after Cardiac Death |
title_fullStr | Targeting the Innate Immune Response to Improve Cardiac Graft Recovery after Heart Transplantation: Implications for the Donation after Cardiac Death |
title_full_unstemmed | Targeting the Innate Immune Response to Improve Cardiac Graft Recovery after Heart Transplantation: Implications for the Donation after Cardiac Death |
title_short | Targeting the Innate Immune Response to Improve Cardiac Graft Recovery after Heart Transplantation: Implications for the Donation after Cardiac Death |
title_sort | targeting the innate immune response to improve cardiac graft recovery after heart transplantation: implications for the donation after cardiac death |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926491/ https://www.ncbi.nlm.nih.gov/pubmed/27322252 http://dx.doi.org/10.3390/ijms17060958 |
work_keys_str_mv | AT toldostefano targetingtheinnateimmuneresponsetoimprovecardiacgraftrecoveryafterhearttransplantationimplicationsforthedonationaftercardiacdeath AT quadermohammed targetingtheinnateimmuneresponsetoimprovecardiacgraftrecoveryafterhearttransplantationimplicationsforthedonationaftercardiacdeath AT salloumfadin targetingtheinnateimmuneresponsetoimprovecardiacgraftrecoveryafterhearttransplantationimplicationsforthedonationaftercardiacdeath AT mezzaromaeleonora targetingtheinnateimmuneresponsetoimprovecardiacgraftrecoveryafterhearttransplantationimplicationsforthedonationaftercardiacdeath AT abbateantonio targetingtheinnateimmuneresponsetoimprovecardiacgraftrecoveryafterhearttransplantationimplicationsforthedonationaftercardiacdeath |