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Hypertension: a problem of organ blood flow supply–demand mismatch
This review introduces a new hypothesis that sympathetically mediated hypertensive diseases are caused, in the most part, by the activation of visceral afferent systems that are connected to neural circuits generating sympathetic activity. We consider how organ hypoperfusion and blood flow supply–de...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Future Medicine Ltd
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926521/ https://www.ncbi.nlm.nih.gov/pubmed/27091483 http://dx.doi.org/10.2217/fca.16.5 |
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author | Koeners, Maarten P Lewis, Kirsty E Ford, Anthony P Paton, Julian FR |
author_facet | Koeners, Maarten P Lewis, Kirsty E Ford, Anthony P Paton, Julian FR |
author_sort | Koeners, Maarten P |
collection | PubMed |
description | This review introduces a new hypothesis that sympathetically mediated hypertensive diseases are caused, in the most part, by the activation of visceral afferent systems that are connected to neural circuits generating sympathetic activity. We consider how organ hypoperfusion and blood flow supply–demand mismatch might lead to both sensory hyper-reflexia and aberrant afferent tonicity. We discuss how this may drive sympatho-excitatory-positive feedback and extend across multiple organs initiating, or at least amplifying, sympathetic hyperactivity. The latter, in turn, compounds the challenge to sufficient organ blood flow through heightened vasoconstriction that both maintains and exacerbates hypertension. |
format | Online Article Text |
id | pubmed-4926521 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Future Medicine Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-49265212017-05-01 Hypertension: a problem of organ blood flow supply–demand mismatch Koeners, Maarten P Lewis, Kirsty E Ford, Anthony P Paton, Julian FR Future Cardiol Review This review introduces a new hypothesis that sympathetically mediated hypertensive diseases are caused, in the most part, by the activation of visceral afferent systems that are connected to neural circuits generating sympathetic activity. We consider how organ hypoperfusion and blood flow supply–demand mismatch might lead to both sensory hyper-reflexia and aberrant afferent tonicity. We discuss how this may drive sympatho-excitatory-positive feedback and extend across multiple organs initiating, or at least amplifying, sympathetic hyperactivity. The latter, in turn, compounds the challenge to sufficient organ blood flow through heightened vasoconstriction that both maintains and exacerbates hypertension. Future Medicine Ltd 2016-05 2016-04-19 /pmc/articles/PMC4926521/ /pubmed/27091483 http://dx.doi.org/10.2217/fca.16.5 Text en © Koeners MP This work is licensed under a Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/) |
spellingShingle | Review Koeners, Maarten P Lewis, Kirsty E Ford, Anthony P Paton, Julian FR Hypertension: a problem of organ blood flow supply–demand mismatch |
title | Hypertension: a problem of organ blood flow supply–demand mismatch |
title_full | Hypertension: a problem of organ blood flow supply–demand mismatch |
title_fullStr | Hypertension: a problem of organ blood flow supply–demand mismatch |
title_full_unstemmed | Hypertension: a problem of organ blood flow supply–demand mismatch |
title_short | Hypertension: a problem of organ blood flow supply–demand mismatch |
title_sort | hypertension: a problem of organ blood flow supply–demand mismatch |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926521/ https://www.ncbi.nlm.nih.gov/pubmed/27091483 http://dx.doi.org/10.2217/fca.16.5 |
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