Cargando…

Hypertension: a problem of organ blood flow supply–demand mismatch

This review introduces a new hypothesis that sympathetically mediated hypertensive diseases are caused, in the most part, by the activation of visceral afferent systems that are connected to neural circuits generating sympathetic activity. We consider how organ hypoperfusion and blood flow supply–de...

Descripción completa

Detalles Bibliográficos
Autores principales: Koeners, Maarten P, Lewis, Kirsty E, Ford, Anthony P, Paton, Julian FR
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926521/
https://www.ncbi.nlm.nih.gov/pubmed/27091483
http://dx.doi.org/10.2217/fca.16.5
_version_ 1782440132409819136
author Koeners, Maarten P
Lewis, Kirsty E
Ford, Anthony P
Paton, Julian FR
author_facet Koeners, Maarten P
Lewis, Kirsty E
Ford, Anthony P
Paton, Julian FR
author_sort Koeners, Maarten P
collection PubMed
description This review introduces a new hypothesis that sympathetically mediated hypertensive diseases are caused, in the most part, by the activation of visceral afferent systems that are connected to neural circuits generating sympathetic activity. We consider how organ hypoperfusion and blood flow supply–demand mismatch might lead to both sensory hyper-reflexia and aberrant afferent tonicity. We discuss how this may drive sympatho-excitatory-positive feedback and extend across multiple organs initiating, or at least amplifying, sympathetic hyperactivity. The latter, in turn, compounds the challenge to sufficient organ blood flow through heightened vasoconstriction that both maintains and exacerbates hypertension.
format Online
Article
Text
id pubmed-4926521
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Future Medicine Ltd
record_format MEDLINE/PubMed
spelling pubmed-49265212017-05-01 Hypertension: a problem of organ blood flow supply–demand mismatch Koeners, Maarten P Lewis, Kirsty E Ford, Anthony P Paton, Julian FR Future Cardiol Review This review introduces a new hypothesis that sympathetically mediated hypertensive diseases are caused, in the most part, by the activation of visceral afferent systems that are connected to neural circuits generating sympathetic activity. We consider how organ hypoperfusion and blood flow supply–demand mismatch might lead to both sensory hyper-reflexia and aberrant afferent tonicity. We discuss how this may drive sympatho-excitatory-positive feedback and extend across multiple organs initiating, or at least amplifying, sympathetic hyperactivity. The latter, in turn, compounds the challenge to sufficient organ blood flow through heightened vasoconstriction that both maintains and exacerbates hypertension. Future Medicine Ltd 2016-05 2016-04-19 /pmc/articles/PMC4926521/ /pubmed/27091483 http://dx.doi.org/10.2217/fca.16.5 Text en © Koeners MP This work is licensed under a Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/)
spellingShingle Review
Koeners, Maarten P
Lewis, Kirsty E
Ford, Anthony P
Paton, Julian FR
Hypertension: a problem of organ blood flow supply–demand mismatch
title Hypertension: a problem of organ blood flow supply–demand mismatch
title_full Hypertension: a problem of organ blood flow supply–demand mismatch
title_fullStr Hypertension: a problem of organ blood flow supply–demand mismatch
title_full_unstemmed Hypertension: a problem of organ blood flow supply–demand mismatch
title_short Hypertension: a problem of organ blood flow supply–demand mismatch
title_sort hypertension: a problem of organ blood flow supply–demand mismatch
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926521/
https://www.ncbi.nlm.nih.gov/pubmed/27091483
http://dx.doi.org/10.2217/fca.16.5
work_keys_str_mv AT koenersmaartenp hypertensionaproblemoforganbloodflowsupplydemandmismatch
AT lewiskirstye hypertensionaproblemoforganbloodflowsupplydemandmismatch
AT fordanthonyp hypertensionaproblemoforganbloodflowsupplydemandmismatch
AT patonjulianfr hypertensionaproblemoforganbloodflowsupplydemandmismatch