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Neuroprotective Effects of Memantine in the Retina of Glaucomatous Rats: An Electron Microscopic Study

PURPOSE: In this experimental study, the effects of systemic memantine administration on the retinal ultrastructure of experimentally induced glaucomatous rats were investigated. METHODS: Twenty-four Wistar albino rats were included in this study. Glaucoma was induced by injecting sodium hyaluronate...

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Autores principales: Celiker, Hande, Yuksel, Nursen, Solakoglu, Seyhun, Karabas, Levent, Aktar, Fadime, Caglar, Yusuf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926565/
https://www.ncbi.nlm.nih.gov/pubmed/27413498
http://dx.doi.org/10.4103/2008-322X.183934
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author Celiker, Hande
Yuksel, Nursen
Solakoglu, Seyhun
Karabas, Levent
Aktar, Fadime
Caglar, Yusuf
author_facet Celiker, Hande
Yuksel, Nursen
Solakoglu, Seyhun
Karabas, Levent
Aktar, Fadime
Caglar, Yusuf
author_sort Celiker, Hande
collection PubMed
description PURPOSE: In this experimental study, the effects of systemic memantine administration on the retinal ultrastructure of experimentally induced glaucomatous rats were investigated. METHODS: Twenty-four Wistar albino rats were included in this study. Glaucoma was induced by injecting sodium hyaluronate into the anterior chamber of the rats for a period of three weeks. As a control, 8 rats were sham treated (Group C). Glaucoma induced animals were divided into two groups; Group M (n = 8) received a single daily dose of 10 mg/kg memantine, and Group G received the same volume of saline (n = 8), via intraperitoneal route for a period of six weeks, starting with the induction of glaucoma. Then, all rats were sacrificed and the retinas were prepared for electron microscopic examination. Electron microscopic damage findings were graded between 0 and 4 and mean damage scores for each cell or layer was calculated for each group. Statistical comparison was made between group G and group M. RESULTS: Including the photoreceptor cells, marked ultrastructural changes were observed in the retinas of the animals in group G. The ultrastructural changes in group M were modest and there was no significant cell death. Statistical findings indicated these results. CONCLUSION: Results of the present study suggest that memantine treatment, when started in the early phase of glaucomatous process, may help to preserve the retinal ultrastructure and thus prevent neuronal injury in experimentally induced glaucoma.
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spelling pubmed-49265652016-07-13 Neuroprotective Effects of Memantine in the Retina of Glaucomatous Rats: An Electron Microscopic Study Celiker, Hande Yuksel, Nursen Solakoglu, Seyhun Karabas, Levent Aktar, Fadime Caglar, Yusuf J Ophthalmic Vis Res Original Article PURPOSE: In this experimental study, the effects of systemic memantine administration on the retinal ultrastructure of experimentally induced glaucomatous rats were investigated. METHODS: Twenty-four Wistar albino rats were included in this study. Glaucoma was induced by injecting sodium hyaluronate into the anterior chamber of the rats for a period of three weeks. As a control, 8 rats were sham treated (Group C). Glaucoma induced animals were divided into two groups; Group M (n = 8) received a single daily dose of 10 mg/kg memantine, and Group G received the same volume of saline (n = 8), via intraperitoneal route for a period of six weeks, starting with the induction of glaucoma. Then, all rats were sacrificed and the retinas were prepared for electron microscopic examination. Electron microscopic damage findings were graded between 0 and 4 and mean damage scores for each cell or layer was calculated for each group. Statistical comparison was made between group G and group M. RESULTS: Including the photoreceptor cells, marked ultrastructural changes were observed in the retinas of the animals in group G. The ultrastructural changes in group M were modest and there was no significant cell death. Statistical findings indicated these results. CONCLUSION: Results of the present study suggest that memantine treatment, when started in the early phase of glaucomatous process, may help to preserve the retinal ultrastructure and thus prevent neuronal injury in experimentally induced glaucoma. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC4926565/ /pubmed/27413498 http://dx.doi.org/10.4103/2008-322X.183934 Text en Copyright: © Journal of Ophthalmic and Vision Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Celiker, Hande
Yuksel, Nursen
Solakoglu, Seyhun
Karabas, Levent
Aktar, Fadime
Caglar, Yusuf
Neuroprotective Effects of Memantine in the Retina of Glaucomatous Rats: An Electron Microscopic Study
title Neuroprotective Effects of Memantine in the Retina of Glaucomatous Rats: An Electron Microscopic Study
title_full Neuroprotective Effects of Memantine in the Retina of Glaucomatous Rats: An Electron Microscopic Study
title_fullStr Neuroprotective Effects of Memantine in the Retina of Glaucomatous Rats: An Electron Microscopic Study
title_full_unstemmed Neuroprotective Effects of Memantine in the Retina of Glaucomatous Rats: An Electron Microscopic Study
title_short Neuroprotective Effects of Memantine in the Retina of Glaucomatous Rats: An Electron Microscopic Study
title_sort neuroprotective effects of memantine in the retina of glaucomatous rats: an electron microscopic study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926565/
https://www.ncbi.nlm.nih.gov/pubmed/27413498
http://dx.doi.org/10.4103/2008-322X.183934
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