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Sociocultural variation in attitudes toward use of genetic information and participation in genetic research by race in the United States: implications for precision medicine
Background “Precision medicine” (PM) requires researchers to identify actionable genetic risks and for clinicians to interpret genetic testing results to patients. Whether PM will equally benefit all populations or exacerbate existing disparities is uncertain. Methods We ascertained attitudes toward...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926739/ https://www.ncbi.nlm.nih.gov/pubmed/26984047 http://dx.doi.org/10.1093/jamia/ocv214 |
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author | Dye, Timothy Li, Dongmei Demment, Margaret Groth, Susan Fernandez, Diana Dozier, Ann Chang, Jack |
author_facet | Dye, Timothy Li, Dongmei Demment, Margaret Groth, Susan Fernandez, Diana Dozier, Ann Chang, Jack |
author_sort | Dye, Timothy |
collection | PubMed |
description | Background “Precision medicine” (PM) requires researchers to identify actionable genetic risks and for clinicians to interpret genetic testing results to patients. Whether PM will equally benefit all populations or exacerbate existing disparities is uncertain. Methods We ascertained attitudes toward genetic testing and genetic research by race in the United States using the online Amazon mTurk US workforce (n = 403 White; n = 56 African American (AA)). Generalized linear models were used to test differences in beliefs and preferences by race, adjusting for sociodemographics and prior genetic experience. Results AA were less likely than White to believe that genetic tests should be promoted or made available. Further, AA were less likely to want genetic testing results or to participate in genetic research. Conclusions Important dimensions that underlay PM are not universally accepted by all populations. Without clear attention to concerns, AA communities may not equally benefit from the rapidly-emerging trend in PM-centered research and clinical practice. |
format | Online Article Text |
id | pubmed-4926739 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-49267392017-07-01 Sociocultural variation in attitudes toward use of genetic information and participation in genetic research by race in the United States: implications for precision medicine Dye, Timothy Li, Dongmei Demment, Margaret Groth, Susan Fernandez, Diana Dozier, Ann Chang, Jack J Am Med Inform Assoc Precision Medicine Informatics Background “Precision medicine” (PM) requires researchers to identify actionable genetic risks and for clinicians to interpret genetic testing results to patients. Whether PM will equally benefit all populations or exacerbate existing disparities is uncertain. Methods We ascertained attitudes toward genetic testing and genetic research by race in the United States using the online Amazon mTurk US workforce (n = 403 White; n = 56 African American (AA)). Generalized linear models were used to test differences in beliefs and preferences by race, adjusting for sociodemographics and prior genetic experience. Results AA were less likely than White to believe that genetic tests should be promoted or made available. Further, AA were less likely to want genetic testing results or to participate in genetic research. Conclusions Important dimensions that underlay PM are not universally accepted by all populations. Without clear attention to concerns, AA communities may not equally benefit from the rapidly-emerging trend in PM-centered research and clinical practice. Oxford University Press 2016-07 2016-03-16 /pmc/articles/PMC4926739/ /pubmed/26984047 http://dx.doi.org/10.1093/jamia/ocv214 Text en © The Author 2016. Published by Oxford University Press on behalf of the American Medical Informatics Association. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Precision Medicine Informatics Dye, Timothy Li, Dongmei Demment, Margaret Groth, Susan Fernandez, Diana Dozier, Ann Chang, Jack Sociocultural variation in attitudes toward use of genetic information and participation in genetic research by race in the United States: implications for precision medicine |
title | Sociocultural variation in attitudes toward use of genetic
information and participation in genetic research by race in the United States:
implications for precision medicine |
title_full | Sociocultural variation in attitudes toward use of genetic
information and participation in genetic research by race in the United States:
implications for precision medicine |
title_fullStr | Sociocultural variation in attitudes toward use of genetic
information and participation in genetic research by race in the United States:
implications for precision medicine |
title_full_unstemmed | Sociocultural variation in attitudes toward use of genetic
information and participation in genetic research by race in the United States:
implications for precision medicine |
title_short | Sociocultural variation in attitudes toward use of genetic
information and participation in genetic research by race in the United States:
implications for precision medicine |
title_sort | sociocultural variation in attitudes toward use of genetic
information and participation in genetic research by race in the united states:
implications for precision medicine |
topic | Precision Medicine Informatics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926739/ https://www.ncbi.nlm.nih.gov/pubmed/26984047 http://dx.doi.org/10.1093/jamia/ocv214 |
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