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DNA Damage among Wood Workers Assessed with the Comet Assay

Exposure to wood dust, a human carcinogen, is common in wood-related industries, and millions of workers are occupationally exposed to wood dust worldwide. The comet assay is a rapid, simple, and sensitive method for determining DNA damage. The objective of this study was to investigate the DNA dama...

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Autores principales: Bruschweiler, Evin Danisman, Wild, Pascal, Huynh, Cong Khanh, Savova-Bianchi, Dessislava, Danuser, Brigitta, Hopf, Nancy B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927022/
https://www.ncbi.nlm.nih.gov/pubmed/27398027
http://dx.doi.org/10.4137/EHI.S38344
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author Bruschweiler, Evin Danisman
Wild, Pascal
Huynh, Cong Khanh
Savova-Bianchi, Dessislava
Danuser, Brigitta
Hopf, Nancy B.
author_facet Bruschweiler, Evin Danisman
Wild, Pascal
Huynh, Cong Khanh
Savova-Bianchi, Dessislava
Danuser, Brigitta
Hopf, Nancy B.
author_sort Bruschweiler, Evin Danisman
collection PubMed
description Exposure to wood dust, a human carcinogen, is common in wood-related industries, and millions of workers are occupationally exposed to wood dust worldwide. The comet assay is a rapid, simple, and sensitive method for determining DNA damage. The objective of this study was to investigate the DNA damage associated with occupational exposure to wood dust using the comet assay (peripheral blood samples) among nonsmoking wood workers (n = 31, furniture and construction workers) and controls (n = 19). DNA damage was greater in the group exposed to composite wood products compared to the group exposed to natural woods and controls (P < 0.001). No difference in DNA damage was observed between workers exposed to natural woods and controls (P = 0.13). Duration of exposure and current dust concentrations had no effect on DNA damage. In future studies, workers’ exposures should include cumulative dust concentrations and exposures originating from the binders used in composite wood products.
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spelling pubmed-49270222016-07-09 DNA Damage among Wood Workers Assessed with the Comet Assay Bruschweiler, Evin Danisman Wild, Pascal Huynh, Cong Khanh Savova-Bianchi, Dessislava Danuser, Brigitta Hopf, Nancy B. Environ Health Insights Original Research Exposure to wood dust, a human carcinogen, is common in wood-related industries, and millions of workers are occupationally exposed to wood dust worldwide. The comet assay is a rapid, simple, and sensitive method for determining DNA damage. The objective of this study was to investigate the DNA damage associated with occupational exposure to wood dust using the comet assay (peripheral blood samples) among nonsmoking wood workers (n = 31, furniture and construction workers) and controls (n = 19). DNA damage was greater in the group exposed to composite wood products compared to the group exposed to natural woods and controls (P < 0.001). No difference in DNA damage was observed between workers exposed to natural woods and controls (P = 0.13). Duration of exposure and current dust concentrations had no effect on DNA damage. In future studies, workers’ exposures should include cumulative dust concentrations and exposures originating from the binders used in composite wood products. Libertas Academica 2016-06-28 /pmc/articles/PMC4927022/ /pubmed/27398027 http://dx.doi.org/10.4137/EHI.S38344 Text en © 2016 the author(s), publisher and licensee Libertas Academica Ltd. This is an open-access article distributed under the terms of the Creative Commons CC-BY-NC 3.0 License.
spellingShingle Original Research
Bruschweiler, Evin Danisman
Wild, Pascal
Huynh, Cong Khanh
Savova-Bianchi, Dessislava
Danuser, Brigitta
Hopf, Nancy B.
DNA Damage among Wood Workers Assessed with the Comet Assay
title DNA Damage among Wood Workers Assessed with the Comet Assay
title_full DNA Damage among Wood Workers Assessed with the Comet Assay
title_fullStr DNA Damage among Wood Workers Assessed with the Comet Assay
title_full_unstemmed DNA Damage among Wood Workers Assessed with the Comet Assay
title_short DNA Damage among Wood Workers Assessed with the Comet Assay
title_sort dna damage among wood workers assessed with the comet assay
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927022/
https://www.ncbi.nlm.nih.gov/pubmed/27398027
http://dx.doi.org/10.4137/EHI.S38344
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