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Challenges of Using High-Dose Fractionation Radiotherapy in Combination Therapy
Radiotherapy is crucial and substantially contributes to multimodal cancer treatment. The combination of conventional fractionation radiotherapy (CFRT) and systemic therapy has been established as the standard treatment for many cancer types. With advances in linear accelerators and image-guided tec...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927577/ https://www.ncbi.nlm.nih.gov/pubmed/27446811 http://dx.doi.org/10.3389/fonc.2016.00165 |
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author | Yang, Ying-Chieh Chiang, Chi-Shiun |
author_facet | Yang, Ying-Chieh Chiang, Chi-Shiun |
author_sort | Yang, Ying-Chieh |
collection | PubMed |
description | Radiotherapy is crucial and substantially contributes to multimodal cancer treatment. The combination of conventional fractionation radiotherapy (CFRT) and systemic therapy has been established as the standard treatment for many cancer types. With advances in linear accelerators and image-guided techniques, high-dose fractionation radiotherapy (HFRT) is increasingly introduced in cancer centers. Clinicians are currently integrating HFRT into multimodality treatment. The shift from CFRT to HFRT reveals different effects on the tumor microenvironment and responses, particularly the immune response. Furthermore, the combination of HFRT and drugs yields different results in different types of tumors or using different treatment schemes. We have reviewed clinical trials and preclinical evidence on the combination of HFRT with drugs, such as chemotherapy, targeted therapy, and immune therapy. Notably, HFRT apparently enhances tumor cell killing and antigen presentation, thus providing opportunities and challenges in treating cancer. |
format | Online Article Text |
id | pubmed-4927577 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-49275772016-07-21 Challenges of Using High-Dose Fractionation Radiotherapy in Combination Therapy Yang, Ying-Chieh Chiang, Chi-Shiun Front Oncol Oncology Radiotherapy is crucial and substantially contributes to multimodal cancer treatment. The combination of conventional fractionation radiotherapy (CFRT) and systemic therapy has been established as the standard treatment for many cancer types. With advances in linear accelerators and image-guided techniques, high-dose fractionation radiotherapy (HFRT) is increasingly introduced in cancer centers. Clinicians are currently integrating HFRT into multimodality treatment. The shift from CFRT to HFRT reveals different effects on the tumor microenvironment and responses, particularly the immune response. Furthermore, the combination of HFRT and drugs yields different results in different types of tumors or using different treatment schemes. We have reviewed clinical trials and preclinical evidence on the combination of HFRT with drugs, such as chemotherapy, targeted therapy, and immune therapy. Notably, HFRT apparently enhances tumor cell killing and antigen presentation, thus providing opportunities and challenges in treating cancer. Frontiers Media S.A. 2016-06-30 /pmc/articles/PMC4927577/ /pubmed/27446811 http://dx.doi.org/10.3389/fonc.2016.00165 Text en Copyright © 2016 Yang and Chiang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Yang, Ying-Chieh Chiang, Chi-Shiun Challenges of Using High-Dose Fractionation Radiotherapy in Combination Therapy |
title | Challenges of Using High-Dose Fractionation Radiotherapy in Combination Therapy |
title_full | Challenges of Using High-Dose Fractionation Radiotherapy in Combination Therapy |
title_fullStr | Challenges of Using High-Dose Fractionation Radiotherapy in Combination Therapy |
title_full_unstemmed | Challenges of Using High-Dose Fractionation Radiotherapy in Combination Therapy |
title_short | Challenges of Using High-Dose Fractionation Radiotherapy in Combination Therapy |
title_sort | challenges of using high-dose fractionation radiotherapy in combination therapy |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927577/ https://www.ncbi.nlm.nih.gov/pubmed/27446811 http://dx.doi.org/10.3389/fonc.2016.00165 |
work_keys_str_mv | AT yangyingchieh challengesofusinghighdosefractionationradiotherapyincombinationtherapy AT chiangchishiun challengesofusinghighdosefractionationradiotherapyincombinationtherapy |