Hemisphere Asymmetry of Response to Pharmacologic Treatment in an Alzheimer’s Disease Mouse Model

The aim of this study was to examine hemisphere asymmetry of response to pharmacologic treatment in an Alzheimer’s disease mouse model using cilostazol as a chemical stimulus. Eight-month-old mice were assigned to vehicle or cilostazol treatment for three months and hemispheres were analyzed using q...

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Autores principales: Manousopoulou, Antigoni, Saito, Satoshi, Yamamoto, Yumi, Al-Daghri, Nasser M., Ihara, Masafumi, Carare, Roxana O., Garbis, Spiros D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2016
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927832/
https://www.ncbi.nlm.nih.gov/pubmed/26836196
http://dx.doi.org/10.3233/JAD-151078
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author Manousopoulou, Antigoni
Saito, Satoshi
Yamamoto, Yumi
Al-Daghri, Nasser M.
Ihara, Masafumi
Carare, Roxana O.
Garbis, Spiros D.
author_facet Manousopoulou, Antigoni
Saito, Satoshi
Yamamoto, Yumi
Al-Daghri, Nasser M.
Ihara, Masafumi
Carare, Roxana O.
Garbis, Spiros D.
author_sort Manousopoulou, Antigoni
collection PubMed
description The aim of this study was to examine hemisphere asymmetry of response to pharmacologic treatment in an Alzheimer’s disease mouse model using cilostazol as a chemical stimulus. Eight-month-old mice were assigned to vehicle or cilostazol treatment for three months and hemispheres were analyzed using quantitative proteomics. Bioinformatics interpretation showed that following treatment, aggregation of blood platelets significantly decreased in the right hemisphere whereas neurodegeneration significantly decreased and synaptic transmission increased in the left hemisphere only. Our study provides novel evidence on cerebral laterality of pharmacologic activity, with important implications in deciphering regional pharmacodynamic effects of existing drugs thus uncovering novel hemisphere-specific therapeutic targets.
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spelling pubmed-49278322016-06-30 Hemisphere Asymmetry of Response to Pharmacologic Treatment in an Alzheimer’s Disease Mouse Model Manousopoulou, Antigoni Saito, Satoshi Yamamoto, Yumi Al-Daghri, Nasser M. Ihara, Masafumi Carare, Roxana O. Garbis, Spiros D. J Alzheimers Dis Short Communication The aim of this study was to examine hemisphere asymmetry of response to pharmacologic treatment in an Alzheimer’s disease mouse model using cilostazol as a chemical stimulus. Eight-month-old mice were assigned to vehicle or cilostazol treatment for three months and hemispheres were analyzed using quantitative proteomics. Bioinformatics interpretation showed that following treatment, aggregation of blood platelets significantly decreased in the right hemisphere whereas neurodegeneration significantly decreased and synaptic transmission increased in the left hemisphere only. Our study provides novel evidence on cerebral laterality of pharmacologic activity, with important implications in deciphering regional pharmacodynamic effects of existing drugs thus uncovering novel hemisphere-specific therapeutic targets. IOS Press 2016-03-15 /pmc/articles/PMC4927832/ /pubmed/26836196 http://dx.doi.org/10.3233/JAD-151078 Text en IOS Press and the authors. All rights reserved https://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Manousopoulou, Antigoni
Saito, Satoshi
Yamamoto, Yumi
Al-Daghri, Nasser M.
Ihara, Masafumi
Carare, Roxana O.
Garbis, Spiros D.
Hemisphere Asymmetry of Response to Pharmacologic Treatment in an Alzheimer’s Disease Mouse Model
title Hemisphere Asymmetry of Response to Pharmacologic Treatment in an Alzheimer’s Disease Mouse Model
title_full Hemisphere Asymmetry of Response to Pharmacologic Treatment in an Alzheimer’s Disease Mouse Model
title_fullStr Hemisphere Asymmetry of Response to Pharmacologic Treatment in an Alzheimer’s Disease Mouse Model
title_full_unstemmed Hemisphere Asymmetry of Response to Pharmacologic Treatment in an Alzheimer’s Disease Mouse Model
title_short Hemisphere Asymmetry of Response to Pharmacologic Treatment in an Alzheimer’s Disease Mouse Model
title_sort hemisphere asymmetry of response to pharmacologic treatment in an alzheimer’s disease mouse model
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927832/
https://www.ncbi.nlm.nih.gov/pubmed/26836196
http://dx.doi.org/10.3233/JAD-151078
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