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Immunization with Small Amyloid-β-derived Cyclopeptide Conjugates Diminishes Amyloid-β-Induced Neurodegeneration in Mice

Background: Soluble oligomeric (misfolded) species of amyloid-β (Aβ) are the main mediators of toxicity in Alzheimer’s disease (AD). These oligomers subsequently form aggregates of insoluble fibrils that precipitate as extracellular and perivascular plaques in the brain. Active immunization against...

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Detalles Bibliográficos
Autores principales:	Mulder, Cornelis K., Dong, Yun, Brugghe, Humphrey F., Timmermans, Hans A.M., Tilstra, Wichard, Westdijk, Janny, van Riet, Elly, van Steeg, Harry, Hoogerhout, Peter, Eisel, Ulrich L.M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	IOS Press 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927839/ https://www.ncbi.nlm.nih.gov/pubmed/27060957 http://dx.doi.org/10.3233/JAD-151136

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