Cargando…

The Synaptic Function of α-Synuclein

α-Synuclein is an abundant neuronal protein which localizes predominantly to presynaptic terminals, and is strongly linked genetically and pathologically to Parkinson’s disease and other neurodegenerative diseases. While the accumulation of α-synuclein in the form of misfolded oligomers and large ag...

Descripción completa

Detalles Bibliográficos
Autor principal:	Burré, Jacqueline
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	IOS Press 2015
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927875/ https://www.ncbi.nlm.nih.gov/pubmed/26407041 http://dx.doi.org/10.3233/JPD-150642

Ejemplares similares

Synaptic vesicle binding of α-synuclein is modulated by β- and γ-synucleins
por: Carnazza, Kathryn E., et al.
Publicado: (2022)

Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2
por: Diao, Jiajie, et al.
Publicado: (2013)

Neutral lysophosphatidylcholine mediates α-synuclein-induced synaptic vesicle clustering
por: Lai, Ying, et al.
Publicado: (2023)

Lysosomal exocytosis releases pathogenic α-synuclein species from neurons in synucleinopathy models
por: Xie, Ying Xue, et al.
Publicado: (2022)

Functional cooperation of α-synuclein and VAMP2 in synaptic vesicle recycling
por: Sun, Jichao, et al.
Publicado: (2019)

Mitochondrial Dysfunction and α-Synuclein Synaptic Pathology in Parkinson's Disease: Who's on First?
por: Zaltieri, Michela, et al.
Publicado: (2015)

Structural basis of synaptic vesicle assembly promoted by α-synuclein
por: Fusco, Giuliana, et al.
Publicado: (2016)

Corrigendum: Structural basis of synaptic vesicle assembly promoted by α-synuclein
por: Fusco, Giuliana, et al.
Publicado: (2017)

From Synaptic Protein to Prion: The Long and Controversial Journey of α-Synuclein
por: Heras-Garvin, Antonio, et al.
Publicado: (2020)

The synaptic pathology of α-synuclein aggregation in dementia with Lewy bodies, Parkinson’s disease and Parkinson’s disease dementia
por: Schulz-Schaeffer, Walter J.
Publicado: (2010)

Rab11 modulates α-synuclein-mediated defects in synaptic transmission and behaviour
por: Breda, Carlo, et al.
Publicado: (2015)

Sideroflexin 3 is an α-synuclein-dependent mitochondrial protein that regulates synaptic morphology
por: Amorim, Inês S., et al.
Publicado: (2017)

C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction
por: Lautenschläger, Janin, et al.
Publicado: (2018)

A Role of Cholesterol in Modulating the Binding of α-Synuclein to Synaptic-Like Vesicles
por: Man, Wing K., et al.
Publicado: (2020)

Effects of Excess Brain-Derived Human α-Synuclein on Synaptic Vesicle Trafficking
por: Román-Vendrell, Cristina, et al.
Publicado: (2021)

α-Synuclein in the Synaptic Vesicle Liquid Phase: Active Player or Passive Bystander?
por: Brodin, Lennart, et al.
Publicado: (2022)

Synaptotagmin-1 and -7 Are Redundantly Essential for Maintaining the Capacity of the Readily-Releasable Pool of Synaptic Vesicles
por: Bacaj, Taulant, et al.
Publicado: (2015)

Structural and Functional Insights into α-Synuclein Fibril Polymorphism
por: Mehra, Surabhi, et al.
Publicado: (2021)

Functionalization of α-synuclein fibrils
por: Povilonienė, Simona, et al.
Publicado: (2015)

Monitoring α-synuclein aggregation
por: Estaun-Panzano, Juan, et al.
Publicado: (2023)

Absence of α-synuclein affects dopamine metabolism and synaptic markers in the striatum of aging mice()
por: Al-Wandi, Abdelmojib, et al.
Publicado: (2010)

Exogenous α-synuclein hinders synaptic communication in cultured cortical primary rat neurons
por: Hassink, G. C., et al.
Publicado: (2018)

Early synaptic dysfunction induced by α-synuclein in a rat model of Parkinson’s disease
por: Phan, Jenny-Ann, et al.
Publicado: (2017)

Chaperone proteins as ameliorators of α-synuclein-induced synaptic pathologies: insights into Parkinson’s disease
por: Banks, Susan M.L., et al.
Publicado: (2020)

The docking of synaptic vesicles on the presynaptic membrane induced by α-synuclein is modulated by lipid composition
por: Man, Wing K., et al.
Publicado: (2021)

Dopamine-dependent early synaptic and motor dysfunctions induced by α-synuclein in the nigrostriatal circuit
por: Tozzi, Alessandro, et al.
Publicado: (2021)

Hsc70 rescues the synaptic vesicle trafficking defects caused by α-synuclein dimers
por: Brady, Emily B., et al.
Publicado: (2023)

α-Synuclein propagation leads to synaptic abnormalities in the cortex through microglial synapse phagocytosis
por: Pérez-Acuña, Dayana, et al.
Publicado: (2023)

The Aggregation of Huntingtin and α-Synuclein
por: Chánez-Cárdenas, María Elena, et al.
Publicado: (2012)

Synapsins regulate α-synuclein functions
por: Atias, Merav, et al.
Publicado: (2019)

The Interplay between α-Synuclein and Microglia in α-Synucleinopathies
por: Deyell, Jacob S., et al.
Publicado: (2023)

α-Synuclein and neuronal cell death
por: Cookson, Mark R
Publicado: (2009)

Neurodegeneration and the ordered assembly of α-synuclein
por: Spillantini, Maria Grazia, et al.
Publicado: (2017)

Cell Responses to Extracellular α-Synuclein
por: Surguchev, Alexei A., et al.
Publicado: (2019)

α-synuclein in the pathophysiology of Alzheimer’s disease
por: Twohig, Daniel, et al.
Publicado: (2019)

Roles for α-Synuclein in Gene Expression
por: Somayaji, Mahalakshmi, et al.
Publicado: (2021)

α-Synuclein and Mechanisms of Epigenetic Regulation
por: Surguchov, Andrei
Publicado: (2023)

Possible Alterations in β-Synuclein, the Non-Amyloidogenic Homologue of α-Synuclein, during Progression of Sporadic α-Synucleinopathies
por: Fujita, Masayo, et al.
Publicado: (2012)

Structural Ensembles of Membrane-bound α-Synuclein Reveal the Molecular Determinants of Synaptic Vesicle Affinity
por: Fusco, Giuliana, et al.
Publicado: (2016)

Acute increase of α-synuclein inhibits synaptic vesicle recycling evoked during intense stimulation
por: Busch, David J., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_8aecpt9b3t3vkklnk6qo16huqb