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Longitudinal Relationships between Caloric Expenditure and Gray Matter in the Cardiovascular Health Study

Background: Physical activity (PA) can be neuroprotective and reduce the risk for Alzheimer’s disease (AD). In assessing physical activity, caloric expenditure is a proxy marker reflecting the sum total of multiple physical activity types conducted by an individual. Objective:To assess caloric expen...

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Autores principales: Raji, Cyrus A., Merrill, David A., Eyre, Harris, Mallam, Sravya, Torosyan, Nare, Erickson, Kirk I., Lopez, Oscar L., Becker, James T., Carmichael, Owen T., Gach, H. Michael, Thompson, Paul M., Longstreth, W.T., Kuller, Lewis H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927887/
https://www.ncbi.nlm.nih.gov/pubmed/26967227
http://dx.doi.org/10.3233/JAD-160057
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author Raji, Cyrus A.
Merrill, David A.
Eyre, Harris
Mallam, Sravya
Torosyan, Nare
Erickson, Kirk I.
Lopez, Oscar L.
Becker, James T.
Carmichael, Owen T.
Gach, H. Michael
Thompson, Paul M.
Longstreth, W.T.
Kuller, Lewis H.
author_facet Raji, Cyrus A.
Merrill, David A.
Eyre, Harris
Mallam, Sravya
Torosyan, Nare
Erickson, Kirk I.
Lopez, Oscar L.
Becker, James T.
Carmichael, Owen T.
Gach, H. Michael
Thompson, Paul M.
Longstreth, W.T.
Kuller, Lewis H.
author_sort Raji, Cyrus A.
collection PubMed
description Background: Physical activity (PA) can be neuroprotective and reduce the risk for Alzheimer’s disease (AD). In assessing physical activity, caloric expenditure is a proxy marker reflecting the sum total of multiple physical activity types conducted by an individual. Objective:To assess caloric expenditure, as a proxy marker of PA, as a predictive measure of gray matter (GM) volumes in the normal and cognitively impaired elderly persons. Methods: All subjects in this study were recruited from the Institutional Review Board approved Cardiovascular Health Study (CHS), a multisite population-based longitudinal study in persons aged 65 and older. We analyzed a sub-sample of CHS participants 876 subjects (mean age 78.3, 57.5% F, 42.5% M) who had i) energy output assessed as kilocalories (kcal) per week using the standardized Minnesota Leisure-Time Activities questionnaire, ii) cognitive assessments for clinical classification of normal cognition, mild cognitive impairment (MCI), and AD, and iii) volumetric MR imaging of the brain. Voxel-based morphometry modeled the relationship between kcal/week and GM volumes while accounting for standard covariates including head size, age, sex, white matter hyperintensity lesions, MCI or AD status, and site. Multiple comparisons were controlled using a False Discovery Rate of 5 percent. Results: Higher energy output, from a variety of physical activity types, was associated with larger GM volumes in frontal, temporal, and parietal lobes, as well as hippocampus, thalamus, and basal ganglia. High levels of caloric expenditure moderated neurodegeneration-associated volume loss in the precuneus, posterior cingulate, and cerebellar vermis. Conclusion:Increasing energy output from a variety of physical activities is related to larger gray matter volumes in the elderly, regardless of cognitive status.
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spelling pubmed-49278872016-06-30 Longitudinal Relationships between Caloric Expenditure and Gray Matter in the Cardiovascular Health Study Raji, Cyrus A. Merrill, David A. Eyre, Harris Mallam, Sravya Torosyan, Nare Erickson, Kirk I. Lopez, Oscar L. Becker, James T. Carmichael, Owen T. Gach, H. Michael Thompson, Paul M. Longstreth, W.T. Kuller, Lewis H. J Alzheimers Dis Research Article Background: Physical activity (PA) can be neuroprotective and reduce the risk for Alzheimer’s disease (AD). In assessing physical activity, caloric expenditure is a proxy marker reflecting the sum total of multiple physical activity types conducted by an individual. Objective:To assess caloric expenditure, as a proxy marker of PA, as a predictive measure of gray matter (GM) volumes in the normal and cognitively impaired elderly persons. Methods: All subjects in this study were recruited from the Institutional Review Board approved Cardiovascular Health Study (CHS), a multisite population-based longitudinal study in persons aged 65 and older. We analyzed a sub-sample of CHS participants 876 subjects (mean age 78.3, 57.5% F, 42.5% M) who had i) energy output assessed as kilocalories (kcal) per week using the standardized Minnesota Leisure-Time Activities questionnaire, ii) cognitive assessments for clinical classification of normal cognition, mild cognitive impairment (MCI), and AD, and iii) volumetric MR imaging of the brain. Voxel-based morphometry modeled the relationship between kcal/week and GM volumes while accounting for standard covariates including head size, age, sex, white matter hyperintensity lesions, MCI or AD status, and site. Multiple comparisons were controlled using a False Discovery Rate of 5 percent. Results: Higher energy output, from a variety of physical activity types, was associated with larger GM volumes in frontal, temporal, and parietal lobes, as well as hippocampus, thalamus, and basal ganglia. High levels of caloric expenditure moderated neurodegeneration-associated volume loss in the precuneus, posterior cingulate, and cerebellar vermis. Conclusion:Increasing energy output from a variety of physical activities is related to larger gray matter volumes in the elderly, regardless of cognitive status. IOS Press 2016-05-10 /pmc/articles/PMC4927887/ /pubmed/26967227 http://dx.doi.org/10.3233/JAD-160057 Text en IOS Press and the authors. All rights reserved https://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Raji, Cyrus A.
Merrill, David A.
Eyre, Harris
Mallam, Sravya
Torosyan, Nare
Erickson, Kirk I.
Lopez, Oscar L.
Becker, James T.
Carmichael, Owen T.
Gach, H. Michael
Thompson, Paul M.
Longstreth, W.T.
Kuller, Lewis H.
Longitudinal Relationships between Caloric Expenditure and Gray Matter in the Cardiovascular Health Study
title Longitudinal Relationships between Caloric Expenditure and Gray Matter in the Cardiovascular Health Study
title_full Longitudinal Relationships between Caloric Expenditure and Gray Matter in the Cardiovascular Health Study
title_fullStr Longitudinal Relationships between Caloric Expenditure and Gray Matter in the Cardiovascular Health Study
title_full_unstemmed Longitudinal Relationships between Caloric Expenditure and Gray Matter in the Cardiovascular Health Study
title_short Longitudinal Relationships between Caloric Expenditure and Gray Matter in the Cardiovascular Health Study
title_sort longitudinal relationships between caloric expenditure and gray matter in the cardiovascular health study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927887/
https://www.ncbi.nlm.nih.gov/pubmed/26967227
http://dx.doi.org/10.3233/JAD-160057
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