Cargando…

Analysis of the Inhibitory Elements in the p5 Peptide Fragment of the CDK5 Activator, p35, CDKR1 Protein

Besides the hallmark pathology of amyloid plaques and neurofibrillary tangles, it is well documented that cyclin-dependent kinase 5 (CDK5), a critical neuronal protein kinase in nervous system development, function, and survival, when deregulated and hyperactivated induces Alzheimer’s disease (AD) a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Binukumar, B.K., Shukla, Varsha, Amin, Niranjana D., Bhaskar, Manju, Skuntz, Suzanne, Steiner, Joseph, Winkler, Dirk, Pelech, Steven L., Pant, Harish C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	IOS Press 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927891/ https://www.ncbi.nlm.nih.gov/pubmed/26444778 http://dx.doi.org/10.3233/JAD-150412

Ejemplares similares

The interaction of Munc 18 (p67) with the p10 domain of p35 protects in vivo Cdk5/p35 activity from inhibition by TFP5, a peptide derived from p35
por: Amin, Niranjana D., et al.
Publicado: (2016)

Peptide TFP5/TP5 derived from Cdk5 activator P35 provides neuroprotection in the MPTP model of Parkinson’s disease
por: Binukumar, BK., et al.
Publicado: (2015)

Knockdown of Expression of Cdk5 or p35 (a Cdk5 Activator) Results in Podocyte Apoptosis
por: Zheng, Ya-Li, et al.
Publicado: (2016)

TP5: A Novel Therapeutic Approach Targeting Aberrant and Hyperactive CDK5/p25 for the Treatment of Colorectal Carcinoma
por: Amin, Niranjana, et al.
Publicado: (2023)

Cdk5 Inhibitory Peptide (CIP) Inhibits Cdk5/p25 Activity Induced by High Glucose in Pancreatic Beta Cells and Recovers Insulin Secretion from p25 Damage
por: Zheng, Ya-Li, et al.
Publicado: (2013)

TFP5/TP5 peptide provides neuroprotection in the MPTP model of Parkinson's disease
por: Binukumar, BK, et al.
Publicado: (2016)

Achaete-scute homologue-1 (ASH1) stimulates migration of lung cancer cells through Cdk5/p35 pathway
por: Demelash, Abeba, et al.
Publicado: (2012)

Therapeutic effects of TP5, a Cdk5/p25 inhibitor, in in vitro and in vivo models of Parkinson’s disease
por: Tran, Judith, et al.
Publicado: (2021)

Effects of p35 Mutations Associated with Mental Retardation on the Cellular Function of p35-CDK5
por: Takada, Shunsuke, et al.
Publicado: (2015)

TP5, a Peptide Inhibitor of Aberrant and Hyperactive CDK5/p25: A Novel Therapeutic Approach against Glioblastoma
por: Tabouret, Emeline, et al.
Publicado: (2020)

Peripheral and orofacial pain sensation is unaffected by the loss of p39
por: Prochazkova, Michaela, et al.
Publicado: (2017)

Mesenchymal Stem Cells Loaded with p5, Derived from CDK5 Activator p35, Inhibit Calcium-Induced CDK5 Activation in Endothelial Cells
por: Fang, Wen-Hui, et al.
Publicado: (2016)

Resveratrol inhibits Cdk5 activity through regulation of p35 expression
por: Utreras, Elias, et al.
Publicado: (2011)

Cdk5/p35 functions as a crucial regulator of spatial learning and memory
por: Mishiba, Tomohide, et al.
Publicado: (2014)

Targeting p35/Cdk5 Signalling via CIP-Peptide Promotes Angiogenesis in Hypoxia
por: Bosutti, Alessandra, et al.
Publicado: (2013)

Involvement of Cdk5 activating subunit p35 in synaptic plasticity in excitatory and inhibitory neurons
por: Takahashi, Miyuki, et al.
Publicado: (2022)

Vps35 Deficiency Impairs Cdk5/p35 Degradation and Promotes the Hyperphosphorylation of Tau Protein in Retinal Ganglion Cells
por: Gao, Ling, et al.
Publicado: (2020)

Cyclin-Dependent Kinase 5 Regulates cPLA2 Activity and Neuroinflammation in Parkinson’s Disease
por: Paul, Sangita, et al.
Publicado: (2022)

Absence of the Cdk5 activator p35 causes adult-onset neurodegeneration in the central brain of Drosophila
por: Trunova, Svetlana, et al.
Publicado: (2012)

CDK5 and Its Activator P35 in Normal Pituitary and in Pituitary Adenomas: Relationship to VEGF Expression
por: Xie, Weiyan, et al.
Publicado: (2014)

Phosphorylation of p27(Kip1) at Thr187 by Cyclin-dependent Kinase 5 Modulates Neural Stem Cell Differentiation
por: Zheng, Ya-Li, et al.
Publicado: (2010)

Cyclin-Dependent Kinase 5/p35/p39: A Novel and Imminent Therapeutic Target for Diabetes Mellitus
por: Ahmed, Danish, et al.
Publicado: (2011)

Searching for Novel Cdk5 Substrates in Brain by Comparative Phosphoproteomics of Wild Type and Cdk5(−/−) Mice
por: Contreras-Vallejos, Erick, et al.
Publicado: (2014)

Involvement of Calpain/p35-p25/Cdk5/NMDAR Signaling Pathway in Glutamate-Induced Neurotoxicity in Cultured Rat Retinal Neurons
por: Miao, Yanying, et al.
Publicado: (2012)

TFP5 peptide, derived from CDK5-activating cofactor p35, provides neuroprotection in early-stage of adult ischemic stroke
por: Ji, Ya-Bin, et al.
Publicado: (2017)

Early protection to stress mediated by CDK-dependent PI3,5P(2) signaling from the vacuole/lysosome
por: Jin, Natsuko, et al.
Publicado: (2017)

A Cdk5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes
por: Pao, Ping-Chieh, et al.
Publicado: (2023)

Prenatal alcohol exposure alters p35, CDK5 and GSK3β in the medial frontal cortex and hippocampus of adolescent mice
por: Goggin, Samantha L., et al.
Publicado: (2014)

Ginsenoside Rb1 Improves Cognitive Impairment Induced by Insulin Resistance through Cdk5/p35-NMDAR-IDE Pathway
por: Yang, Ranyao, et al.
Publicado: (2020)

Prenatal p,p´-DDE Exposure and Neurodevelopment among Children 3.5–5 Years of Age
por: Torres-Sánchez, Luisa, et al.
Publicado: (2012)

The protective effects of TanIIA on neurotoxicity induced by β-amyloid protein through the Cdk5/P35 pathway in cultured primary neurons
por: Shi, Lili, et al.
Publicado: (2012)

p39-associated Cdk5 activity regulates dendritic morphogenesis
por: Ouyang, Li, et al.
Publicado: (2020)

Cell-Penetrating Fragments of the Cdk5 Regulatory Subunit Are Protective in Models of Neurodegeneration
por: Liman, Jan, et al.
Publicado: (2010)

$ K^{+}p $ elastic scattering at 3.5 and 5.0 GeV/c
por: De Baere, W, et al.
Publicado: (1966)

Altered expression of the Cdk5 activator-like protein, Cdk5α, causes neurodegeneration, in part by accelerating the rate of aging
por: Spurrier, Joshua, et al.
Publicado: (2018)

PI(3,5)P(2) sows the seeds of plant growth
por: Short, Ben
Publicado: (2012)

Study of the reactions K$^{+}$p --> K$^{*}$ N$^{*}$ at 3.5 and 5 GeV/c
por: George, R, et al.
Publicado: (1966)

Study of the reactions $K^{+}p$ -> $K^{*} N^{*}$ at 3.5 and 5 GeV/c
por: George, R, et al.
Publicado: (1967)

Biological functions of CDK5 and potential CDK5 targeted clinical treatments
por: Shupp, Alison, et al.
Publicado: (2017)

ING5 Is Phosphorylated by CDK2 and Controls Cell Proliferation Independently of p53
por: Linzen, Ulrike, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_ajrcgeq0tg34nant238n18bihf