Cognitive Stimulation Modulates Platelet Total Phospholipases A(2) Activity in Subjects with Mild Cognitive Impairment

We evaluated the effect of cognitive stimulation (CS) on platelet total phospholipases A(2) activity (tPLA(2)A) in patients with mild cognitive impairment (MCI_P). At baseline, tPLA(2)A negatively correlated with Mini-Mental State Examination score (MMSE_s): patients with MMSE_s <26 (Subgroup 1)...

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Detalles Bibliográficos
Autores principales: Balietti, Marta, Giuli, Cinzia, Fattoretti, Patrizia, Fabbietti, Paolo, Postacchini, Demetrio, Conti, Fiorenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2016
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927922/
https://www.ncbi.nlm.nih.gov/pubmed/26836161
http://dx.doi.org/10.3233/JAD-150714
Descripción
Sumario:We evaluated the effect of cognitive stimulation (CS) on platelet total phospholipases A(2) activity (tPLA(2)A) in patients with mild cognitive impairment (MCI_P). At baseline, tPLA(2)A negatively correlated with Mini-Mental State Examination score (MMSE_s): patients with MMSE_s <26 (Subgroup 1) had significantly higher activity than those with MMSE_s ≥26 (Subgroup 2), who had values similar to the healthy elderly. Regarding CS effect, Subgroup 1 had a significant tPLA(2)A reduction, whereas Subgroup 2 did not significantly changes after training. Our results showed for the first time that tPLA(2)A correlates with the cognitive conditions of MCI_P, and that CS acts selectively on subjects with a dysregulated tPLA(2)A.

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