Cognitive Stimulation Modulates Platelet Total Phospholipases A(2) Activity in Subjects with Mild Cognitive Impairment

We evaluated the effect of cognitive stimulation (CS) on platelet total phospholipases A(2) activity (tPLA(2)A) in patients with mild cognitive impairment (MCI_P). At baseline, tPLA(2)A negatively correlated with Mini-Mental State Examination score (MMSE_s): patients with MMSE_s <26 (Subgroup 1)...

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Detalles Bibliográficos
Autores principales: Balietti, Marta, Giuli, Cinzia, Fattoretti, Patrizia, Fabbietti, Paolo, Postacchini, Demetrio, Conti, Fiorenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2016
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927922/
https://www.ncbi.nlm.nih.gov/pubmed/26836161
http://dx.doi.org/10.3233/JAD-150714
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author Balietti, Marta
Giuli, Cinzia
Fattoretti, Patrizia
Fabbietti, Paolo
Postacchini, Demetrio
Conti, Fiorenzo
author_facet Balietti, Marta
Giuli, Cinzia
Fattoretti, Patrizia
Fabbietti, Paolo
Postacchini, Demetrio
Conti, Fiorenzo
author_sort Balietti, Marta
collection PubMed
description We evaluated the effect of cognitive stimulation (CS) on platelet total phospholipases A(2) activity (tPLA(2)A) in patients with mild cognitive impairment (MCI_P). At baseline, tPLA(2)A negatively correlated with Mini-Mental State Examination score (MMSE_s): patients with MMSE_s <26 (Subgroup 1) had significantly higher activity than those with MMSE_s ≥26 (Subgroup 2), who had values similar to the healthy elderly. Regarding CS effect, Subgroup 1 had a significant tPLA(2)A reduction, whereas Subgroup 2 did not significantly changes after training. Our results showed for the first time that tPLA(2)A correlates with the cognitive conditions of MCI_P, and that CS acts selectively on subjects with a dysregulated tPLA(2)A.
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spelling pubmed-49279222016-06-30 Cognitive Stimulation Modulates Platelet Total Phospholipases A(2) Activity in Subjects with Mild Cognitive Impairment Balietti, Marta Giuli, Cinzia Fattoretti, Patrizia Fabbietti, Paolo Postacchini, Demetrio Conti, Fiorenzo J Alzheimers Dis Short Communication We evaluated the effect of cognitive stimulation (CS) on platelet total phospholipases A(2) activity (tPLA(2)A) in patients with mild cognitive impairment (MCI_P). At baseline, tPLA(2)A negatively correlated with Mini-Mental State Examination score (MMSE_s): patients with MMSE_s <26 (Subgroup 1) had significantly higher activity than those with MMSE_s ≥26 (Subgroup 2), who had values similar to the healthy elderly. Regarding CS effect, Subgroup 1 had a significant tPLA(2)A reduction, whereas Subgroup 2 did not significantly changes after training. Our results showed for the first time that tPLA(2)A correlates with the cognitive conditions of MCI_P, and that CS acts selectively on subjects with a dysregulated tPLA(2)A. IOS Press 2016-02-22 /pmc/articles/PMC4927922/ /pubmed/26836161 http://dx.doi.org/10.3233/JAD-150714 Text en IOS Press and the authors. All rights reserved https://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Balietti, Marta
Giuli, Cinzia
Fattoretti, Patrizia
Fabbietti, Paolo
Postacchini, Demetrio
Conti, Fiorenzo
Cognitive Stimulation Modulates Platelet Total Phospholipases A(2) Activity in Subjects with Mild Cognitive Impairment
title Cognitive Stimulation Modulates Platelet Total Phospholipases A(2) Activity in Subjects with Mild Cognitive Impairment
title_full Cognitive Stimulation Modulates Platelet Total Phospholipases A(2) Activity in Subjects with Mild Cognitive Impairment
title_fullStr Cognitive Stimulation Modulates Platelet Total Phospholipases A(2) Activity in Subjects with Mild Cognitive Impairment
title_full_unstemmed Cognitive Stimulation Modulates Platelet Total Phospholipases A(2) Activity in Subjects with Mild Cognitive Impairment
title_short Cognitive Stimulation Modulates Platelet Total Phospholipases A(2) Activity in Subjects with Mild Cognitive Impairment
title_sort cognitive stimulation modulates platelet total phospholipases a(2) activity in subjects with mild cognitive impairment
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927922/
https://www.ncbi.nlm.nih.gov/pubmed/26836161
http://dx.doi.org/10.3233/JAD-150714
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