Plurihormonal Cosecretion by a Case of Adrenocortical Oncocytic Neoplasm

Adrenocortical oncocytic neoplasms (oncocytomas) are extremely rare; only approximately 159 cases have been described so far. The majority are nonfunctional and benign. We describe an unusual case of a functional oncocytoma secreting an excess of glucocorticoids (cortisol) and androgens (androstened...

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Detalles Bibliográficos
Autores principales: Corrales, J. J., Robles-Lázaro, C., Sánchez-Marcos, A. I., González-Sánchez, M. C., Antúnez-Plaza, P., Miralles, J. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927977/
https://www.ncbi.nlm.nih.gov/pubmed/27413559
http://dx.doi.org/10.1155/2016/6785925
Descripción
Sumario:Adrenocortical oncocytic neoplasms (oncocytomas) are extremely rare; only approximately 159 cases have been described so far. The majority are nonfunctional and benign. We describe an unusual case of a functional oncocytoma secreting an excess of glucocorticoids (cortisol) and androgens (androstenedione and DHEAS), a pattern of plurihormonal cosecretion previously not reported in men, presenting with endocrine manifestations of Cushing's syndrome. The neoplasm was considered to be of uncertain malignant potential (borderline) according to the Lin-Weiss-Bisceglia criteria.

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