Plurihormonal Cosecretion by a Case of Adrenocortical Oncocytic Neoplasm

Adrenocortical oncocytic neoplasms (oncocytomas) are extremely rare; only approximately 159 cases have been described so far. The majority are nonfunctional and benign. We describe an unusual case of a functional oncocytoma secreting an excess of glucocorticoids (cortisol) and androgens (androstened...

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Autores principales: Corrales, J. J., Robles-Lázaro, C., Sánchez-Marcos, A. I., González-Sánchez, M. C., Antúnez-Plaza, P., Miralles, J. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927977/
https://www.ncbi.nlm.nih.gov/pubmed/27413559
http://dx.doi.org/10.1155/2016/6785925
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author Corrales, J. J.
Robles-Lázaro, C.
Sánchez-Marcos, A. I.
González-Sánchez, M. C.
Antúnez-Plaza, P.
Miralles, J. M.
author_facet Corrales, J. J.
Robles-Lázaro, C.
Sánchez-Marcos, A. I.
González-Sánchez, M. C.
Antúnez-Plaza, P.
Miralles, J. M.
author_sort Corrales, J. J.
collection PubMed
description Adrenocortical oncocytic neoplasms (oncocytomas) are extremely rare; only approximately 159 cases have been described so far. The majority are nonfunctional and benign. We describe an unusual case of a functional oncocytoma secreting an excess of glucocorticoids (cortisol) and androgens (androstenedione and DHEAS), a pattern of plurihormonal cosecretion previously not reported in men, presenting with endocrine manifestations of Cushing's syndrome. The neoplasm was considered to be of uncertain malignant potential (borderline) according to the Lin-Weiss-Bisceglia criteria.
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spelling pubmed-49279772016-07-13 Plurihormonal Cosecretion by a Case of Adrenocortical Oncocytic Neoplasm Corrales, J. J. Robles-Lázaro, C. Sánchez-Marcos, A. I. González-Sánchez, M. C. Antúnez-Plaza, P. Miralles, J. M. Case Rep Endocrinol Case Report Adrenocortical oncocytic neoplasms (oncocytomas) are extremely rare; only approximately 159 cases have been described so far. The majority are nonfunctional and benign. We describe an unusual case of a functional oncocytoma secreting an excess of glucocorticoids (cortisol) and androgens (androstenedione and DHEAS), a pattern of plurihormonal cosecretion previously not reported in men, presenting with endocrine manifestations of Cushing's syndrome. The neoplasm was considered to be of uncertain malignant potential (borderline) according to the Lin-Weiss-Bisceglia criteria. Hindawi Publishing Corporation 2016 2016-06-16 /pmc/articles/PMC4927977/ /pubmed/27413559 http://dx.doi.org/10.1155/2016/6785925 Text en Copyright © 2016 J. J. Corrales et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Corrales, J. J.
Robles-Lázaro, C.
Sánchez-Marcos, A. I.
González-Sánchez, M. C.
Antúnez-Plaza, P.
Miralles, J. M.
Plurihormonal Cosecretion by a Case of Adrenocortical Oncocytic Neoplasm
title Plurihormonal Cosecretion by a Case of Adrenocortical Oncocytic Neoplasm
title_full Plurihormonal Cosecretion by a Case of Adrenocortical Oncocytic Neoplasm
title_fullStr Plurihormonal Cosecretion by a Case of Adrenocortical Oncocytic Neoplasm
title_full_unstemmed Plurihormonal Cosecretion by a Case of Adrenocortical Oncocytic Neoplasm
title_short Plurihormonal Cosecretion by a Case of Adrenocortical Oncocytic Neoplasm
title_sort plurihormonal cosecretion by a case of adrenocortical oncocytic neoplasm
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927977/
https://www.ncbi.nlm.nih.gov/pubmed/27413559
http://dx.doi.org/10.1155/2016/6785925
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