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Black ethnicity predicts better survival on dialysis despite greater deprivation and co-morbidity: a UK study
Background: Observational studies from the United States have identified black race as conferring a survival advantage on dialysis. This study represents the first large single-center study from a UK dialysis unit examining the outcome of ethnic minorities on renal replacement therapy (RRT). Methods...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dustri-Verlag Dr. Karl Feistle
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928033/ https://www.ncbi.nlm.nih.gov/pubmed/24985953 http://dx.doi.org/10.5414/CN108247 |
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author | Cole, Nicholas Bedford, Michael Cai, Andrew Jones, Chris Cairns, Hugh Jayawardene, Satish |
author_facet | Cole, Nicholas Bedford, Michael Cai, Andrew Jones, Chris Cairns, Hugh Jayawardene, Satish |
author_sort | Cole, Nicholas |
collection | PubMed |
description | Background: Observational studies from the United States have identified black race as conferring a survival advantage on dialysis. This study represents the first large single-center study from a UK dialysis unit examining the outcome of ethnic minorities on renal replacement therapy (RRT). Methods: A retrospective analysis of all patients of white or black race initiating RRT at King’s College Hospital Renal Unit, London, between 1996 and 2008 was performed. A total of 1,340 patients were studied, of which 952 (71%) were of white race, and 388 (29%) were of black race. Kaplan-Meier survival curves, the log rank test and Cox’s proportional hazard models were used to compare survival between groups. Results: The results revealed black ethnicity to be associated with a significant survival benefit on dialysis. This was the case even after adjustment for age, gender, diabetes, transplantation, and deprivation. In those patients not transplanted, black race conferred a hazard ratio (HR) of 0.51 (95% CI 0.41 – 0.63) over 5 years. Conclusions: This study provides evidence for a lower mortality rate amongst black patients on dialysis in comparison with their white counterparts in the UK. The reasons behind this remain poorly understood but a lower incidence of cardiovascular disease in black patients and more kidney-limited disease may be important. |
format | Online Article Text |
id | pubmed-4928033 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Dustri-Verlag Dr. Karl Feistle |
record_format | MEDLINE/PubMed |
spelling | pubmed-49280332016-07-14 Black ethnicity predicts better survival on dialysis despite greater deprivation and co-morbidity: a UK study Cole, Nicholas Bedford, Michael Cai, Andrew Jones, Chris Cairns, Hugh Jayawardene, Satish Clin Nephrol Research Article Background: Observational studies from the United States have identified black race as conferring a survival advantage on dialysis. This study represents the first large single-center study from a UK dialysis unit examining the outcome of ethnic minorities on renal replacement therapy (RRT). Methods: A retrospective analysis of all patients of white or black race initiating RRT at King’s College Hospital Renal Unit, London, between 1996 and 2008 was performed. A total of 1,340 patients were studied, of which 952 (71%) were of white race, and 388 (29%) were of black race. Kaplan-Meier survival curves, the log rank test and Cox’s proportional hazard models were used to compare survival between groups. Results: The results revealed black ethnicity to be associated with a significant survival benefit on dialysis. This was the case even after adjustment for age, gender, diabetes, transplantation, and deprivation. In those patients not transplanted, black race conferred a hazard ratio (HR) of 0.51 (95% CI 0.41 – 0.63) over 5 years. Conclusions: This study provides evidence for a lower mortality rate amongst black patients on dialysis in comparison with their white counterparts in the UK. The reasons behind this remain poorly understood but a lower incidence of cardiovascular disease in black patients and more kidney-limited disease may be important. Dustri-Verlag Dr. Karl Feistle 2014-08 2014-07-02 /pmc/articles/PMC4928033/ /pubmed/24985953 http://dx.doi.org/10.5414/CN108247 Text en © Dustri-Verlag Dr. K. Feistle http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Cole, Nicholas Bedford, Michael Cai, Andrew Jones, Chris Cairns, Hugh Jayawardene, Satish Black ethnicity predicts better survival on dialysis despite greater deprivation and co-morbidity: a UK study |
title | Black ethnicity predicts better survival on dialysis despite greater deprivation and co-morbidity: a UK study |
title_full | Black ethnicity predicts better survival on dialysis despite greater deprivation and co-morbidity: a UK study |
title_fullStr | Black ethnicity predicts better survival on dialysis despite greater deprivation and co-morbidity: a UK study |
title_full_unstemmed | Black ethnicity predicts better survival on dialysis despite greater deprivation and co-morbidity: a UK study |
title_short | Black ethnicity predicts better survival on dialysis despite greater deprivation and co-morbidity: a UK study |
title_sort | black ethnicity predicts better survival on dialysis despite greater deprivation and co-morbidity: a uk study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928033/ https://www.ncbi.nlm.nih.gov/pubmed/24985953 http://dx.doi.org/10.5414/CN108247 |
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