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Methylmercury, an environmental electrophile capable of activation and disruption of the Akt/CREB/Bcl-2 signal transduction pathway in SH-SY5Y cells

Methylmercury (MeHg) modifies cellular proteins via their thiol groups in a process referred to as “S-mercuration”, potentially resulting in modulation of the cellular signal transduction pathway. We examined whether low-dose MeHg could affect Akt signaling involved in cell survival. Exposure of hum...

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Detalles Bibliográficos
Autores principales:	Unoki, Takamitsu, Abiko, Yumi, Toyama, Takashi, Uehara, Takashi, Tsuboi, Koji, Nishida, Motohiro, Kaji, Toshiyuki, Kumagai, Yoshito
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928048/ https://www.ncbi.nlm.nih.gov/pubmed/27357941 http://dx.doi.org/10.1038/srep28944

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